A study of the level of circulating cytokines in patients with atopic dermatitis
- 作者: Volkova Y.N.1, Morozov S.G.2, Tarasova M.V.1, Grigoriyeva A.A.3, Yelistratova I.V.4
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隶属关系:
- The Russian National Research Medical University named after N.I. Pirogov
- Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences
- State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation
- Central Military Clinical Hospital Russian Interior Troops
- 期: 卷 90, 编号 2 (2014)
- 页面: 26-30
- 栏目: ORIGINAL STUDIES
- URL: https://medbiosci.ru/0042-4609/article/view/116582
- DOI: https://doi.org/10.25208/0042-4609-2014-90-2-26-30
- ID: 116582
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详细
Goal of the study. To study the role of pro-inflammatory and anti-inflammatory cytokines for the course of atopic dermatitis (AD). Materials and methods. The study involved 72 patients aged 25-55 suffering from atopic dermatitis for 2-30 years and with at least two relapses a year. The AD patients were assigned to the following groups depending on the SCORAD (iSc) index: Group 1: light form (iSc < 30 points), Group 2: moderate to severe form (iSc from 30 to 50 points) and Group 3: severe form (iSc > 50 points). The control group comprised 23 practically healthy subjects aged 25-35. The level of cytokines (IL-1 β, -4, -6, -8, -10, -12, -13, TNF-α and IFN-γ) in blood serum was determined based on the immune-enzyme assay method. Results. A trend to the increased production of anti-inflammatory cytokines (IL-4, -6, -10, -13) at the exacerbation stage and increased synthesis of pro-inflammatory ones (IFN-γ, TNF-α and IL-12) at the remission stage was observed in patients with atopic dermatitis, which confirms the dysregulation of reciprocal relationships between Th1 and Th2 lymphocyte subpopulations during the disease.
作者简介
YE. Volkova
The Russian National Research Medical University named after N.I. Pirogov
编辑信件的主要联系方式.
Email: volkovaen@cnikvi.ru
俄罗斯联邦
S. Morozov
Federal State Budgetary Institution «Institute of General Pathology and Pathophysiology» under the Russian Academy of Medical Sciences俄罗斯联邦
M. Tarasova
The Russian National Research Medical University named after N.I. Pirogov俄罗斯联邦
A. Grigoriyeva
State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation俄罗斯联邦
I. Yelistratova
Central Military Clinical Hospital Russian Interior Troops俄罗斯联邦
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