Prediction of the risk of developing pulmonary tuberculosis in patients with comorbid pathology of the gastrointestinal tract
- Authors: Mordyk A.V.1,2, Shapran A.A.1,3, Bagisheva N.V.1, Moiseeva M.V.1, Shcherbakova L.E.1,3, Mordyk D.I.4, Kolpakova T.A.5
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Affiliations:
- Omsk State Medical University, Ministry of Health of Russia
- National Medical Research Center for Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia
- Omsk Central District Hospital Russia
- Main bureau of medical and social expertise in the Omsk Region
- Novosibirsk State Medical University, Ministry of Health of Russia
- Issue: Vol 36, No 2 (2025)
- Pages: 79-82
- Section: From Practice
- URL: https://medbiosci.ru/0236-3054/article/view/294254
- DOI: https://doi.org/10.29296/25877305-2025-02-18
- ID: 294254
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Abstract
Gastrointestinal tract (GIT) diseases are widespread among the population, including rural residents. Long-term course without sufficient therapy can lead to protein-energy and immunological deficiency, making patients vulnerable to tuberculosis infection.
Objective. To predict the risk of developing pulmonary tuberculosis (TB) in patients with comorbid gastrointestinal pathology living in rural areas.
Materials and methods. The retrospective study included 268 patients with newly diagnosed TB. In 48 cases, a combination of TB and chronic gastrointestinal diseases was observed. The odds ratio (OR) was used as a tool to determine the risk of developing TB. The factor analysis method was used to determine the temple factors.
Results. The odds ratio (OR), which tells the odds of an event occurring in one group to the odds of an event occurring in another group, was used to determine the risk of developing TB: OR=10.63 (CI: 7.75–14.58; p<0.001). In the presence of chronic gastritis – OR=7.03 (CI: 4.87–10.15; p<0.001), peptic ulcer disease – OR=112.81 (CI: 61.66–206.42; p<0.001). According to the results of factor analysis, the risk group for developing TB included rural residents, elderly, suffering from peptic ulcer disease, having bad habits (smoking), living in unfavorable conditions with stove heating. TB was detected when they sought medical help with complaints from the bronchopulmonary system.
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##article.viewOnOriginalSite##About the authors
A. V. Mordyk
Omsk State Medical University, Ministry of Health of Russia; National Medical Research Center for Phthisiopulmonology and Infectious Diseases, Ministry of Health of Russia
Author for correspondence.
Email: ppi100@mail.ru
ORCID iD: 0000-0001-6196-7256
SPIN-code: 6795-8051
Professor, MD
Russian Federation, Omsk; MoscowA. A. Shapran
Omsk State Medical University, Ministry of Health of Russia; Omsk Central District Hospital Russia
Email: ppi100@mail.ru
ORCID iD: 0009-0008-6729-7116
Russian Federation, Omsk; Omsk
N. V. Bagisheva
Omsk State Medical University, Ministry of Health of Russia
Email: ppi100@mail.ru
ORCID iD: 0000-0003-3668-1023
SPIN-code: 5892-9495
MD
Russian Federation, OmskM. V. Moiseeva
Omsk State Medical University, Ministry of Health of Russia
Email: ppi100@mail.ru
ORCID iD: 0000-0003-3458-9346
SPIN-code: 4166-5859
Candidate of Medical Sciences
Russian Federation, OmskL. E. Shcherbakova
Omsk State Medical University, Ministry of Health of Russia; Omsk Central District Hospital Russia
Email: ppi100@mail.ru
ORCID iD: 0009-0006-1997-8246
Russian Federation, Omsk; Omsk
D. I. Mordyk
Main bureau of medical and social expertise in the Omsk Region
Email: ppi100@mail.ru
Bureau No. 17
Russian Federation, OmskT. A. Kolpakova
Novosibirsk State Medical University, Ministry of Health of Russia
Email: ppi100@mail.ru
ORCID iD: 0000-0001-9718-2020
SPIN-code: 1875-7930
MD
Russian Federation, NovosibirskReferences
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