Selection and evaluation of high molecular weight compounds for the development of a gel base
- Авторлар: Alhamwi O.1, Zhilyakova E.T.1
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Мекемелер:
- Federal State Autonomous Educational Institution of Higher Education «Belgorod State National Research University»
- Шығарылым: Том 74, № 4 (2025)
- Беттер: 38-43
- Бөлім: Technology of medicines
- URL: https://medbiosci.ru/0367-3014/article/view/314371
- DOI: https://doi.org/10.29296/25419218-2025-04-05
- ID: 314371
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Аннотация
Introduction: gels, as a medicinal and cosmetic form, are widely used in medicine and cosmetology and consist of a gel base and a medicinal substance distributed in it, therefore development of a suitable gel base begins with the selection of high molecular weight compounds at the optimal concentration that impart the appropriate rheological properties to the desired dosage form. In this work, solutions of polymer gels (HPMC, carbopol and sodium alginate) of various concentrations were prepared to conduct tests and determine their properties.
Purpose: the purpose of the study was to study the properties of high molecular weight compounds to use it for developing a gel bases.
Material and methods: To achieve this goal, polymer gels of various concentrations were prepared and rheological and technological properties were studied: viscosity, shear resistance, spreadability, covering ability.
Results: the results obtained showed that the studied polymer gels have the desired properties, such as unifed coverage on the skin area and the ability to return to its original viscosity after deformation.
Conclusion: the study made it possible to identify promising gelling agents that can be used for the development of a gel preparations due to their high efficiency and ease of use.
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##article.viewOnOriginalSite##Авторлар туралы
Ola Alhamwi
Federal State Autonomous Educational Institution of Higher Education «Belgorod State National Research University»
Хат алмасуға жауапты Автор.
Email: Olaalhamwi6@gmail.com
ORCID iD: 0009-0002-7601-599X
SPIN-код: 6815-4459
1st Year Postgraduate Student in a scientific specialty Industrial pharmacy and drug production technology
Ресей, 308015, Belgorod, 85, Pobedy St.Elena Zhilyakova
Federal State Autonomous Educational Institution of Higher Education «Belgorod State National Research University»
Email: EZhilyakova@bsu.edu.ru
ORCID iD: 0000-0002-8685-1601
SPIN-код: 9169-7991
Head of the Department of Pharmaceutical Technology, Institute of pharmacy, chemistry and biology, Doctor of pharmaceutical sciences, Professor
Ресей, 308015, Belgorod, 85, Pobedy St.Әдебиет тізімі
- Жилякова Е.Т., Алхамви О. Фармацевтический Рынок Сирийской Арабской Республики Противогрибковых Лекарственных Препаратов. 2023. [Zhilyakova E.T., Alhamwi O. Pharmaceutical market of the Syrian Arab Republic of antifungal drugs. Pharmaceutical Bulletin of the South of Russia. 2023; 1 (77): 44–49. (in Russian)]
- Nautiyal U., Sahu N., Gupta D. Hydrogel: Preparation, Characterization and Applications. Asian Pacific J. of Nursing and Health Sciences. 2020; 3. 10.46811/apjnh/3.1.1.
- Chamkouri H. A Review of Hydrogels, Their Properties and Applications in Medicine. American J. of Biomedical Science & Research. 2021; 11: 485–93. 10.34297/AJBSR.2021.11.001682.
- Siddique W., Zaman M., Khan R., Butt M.Н., Asghar F., Shamim Q., Malik T. et al. Formulation and Evaluation of Hydroxypropyl Methylcellulose Based Topical Gel Loaded with Ganciclovir. 2022.
- Dayani L., Taheri А., Taymouri S., Bahri Najafi R., Esmaeilian F. Preparation and in vitro evaluation of Vancomycin loaded Montmorillonite-Sodium Alginate topical gel for wound infection. 2022. http://dx.doi.org/10.1590/s2175-97902022e21034
- Safitri F., Nawangsari D., Febrina D. Overview: Application of Carbopol 940 in Gel. 2021. 10.2991/ahsr.k.210127.018
- Schweizer T. Rheology. Concepts, Methods, and Applications. Applied Rheology. 2019; 16: 240–1. 10.1515/arh-2006-0039.
- Bakhrushina E.O., Anurova M.N., Zavalniy M.S., Demina N.B., Bardakov A.I., Krasnyuk I.I., Dermatologic Gels Spreadability Measuring Methods Comparative Study. Int. J. Appl Pharm. 2022; 14 (1): 164–8. doi: 10.22159/ijap.2022v14i1.41267
- Shiva K., Mandal S., Kumar S. Formulation And Evaluation of Topical Antifungal Gel of Fluconazole Using Aloe Vera Gel. International Journal of Scientific Development and Research (IJSDR). 2021. ISSN: 2455-2631
- ГОСТ 31695–2012. Гели косметические. Общие технические условия. М.: Стандартинформ, 2013; 8. [GOST 31695–2012. Cosmetic gels. General technical specifications. Moscow: Standartinform, 2013; 8 (in Russian)]
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