SUBPOPULATIONS OF MYELOID DERIVED SUPRESSORS CELLS IN CHILDREN WITH PSORIASIS
- 作者: Gerasimova D.G.1, Radygina T.V.1, Zakirov R.S.1, Ambarchyan A.I.1, Materikin A.I.1, Epishev N.N.1, Murashkin A.I.1, Petrichuk S.V.1
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隶属关系:
- National Medical Research Center for Children’s Health
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 200-201
- 栏目: ORIGINAL ARTICLES
- URL: https://medbiosci.ru/1028-7221/article/view/119554
- DOI: https://doi.org/10.31857/S102872210006457-7
- ID: 119554
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详细
The absolute and relative number of myeloid derived suppressor cells, regulatory T-lymphocytes and Th17-lymphocytes were assessed in 115 patients with psoriasis and 53 healthy children aged 1.5 to 18 years. An increase in the number of MDSCs due to G-MDSCs was found, depending on the duration of the disease. As the severity of the disease increases, the relative number of M-MDSCs increases. The number of MDSCs directly correlates with the number of Th17 lymphocytes and Treg.
作者简介
D. Gerasimova
National Medical Research Center for Children’s Health
resident, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦T. Radygina
National Medical Research Center for Children’s Health
Ph D., Senior Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦R. Zakirov
National Medical Research Center for Children’s Health
Doctor of clinical laboratory,
Moscow
俄罗斯联邦A. Ambarchyan
National Medical Research Center for Children’s Health
Research Associate, Laboratory Skin Phatology in children,
Moscow
俄罗斯联邦A. Materikin
National Medical Research Center for Children’s Health
Dermatologist, Department of Dermatology,
Moscow
俄罗斯联邦N. Epishev
National Medical Research Center for Children’s Health
Dermatovenerologist, Department of Dermatology,
Moscow
俄罗斯联邦A. Murashkin
National Medical Research Center for Children’s Health
PhD, MD, Head of the Laboratory Skin Phatology in children,
Moscow
俄罗斯联邦S. Petrichuk
National Medical Research Center for Children’s Health
编辑信件的主要联系方式.
Email: cito@list.ru
PhD, MD (Biology), Professor, Principal Research Associate, Laboratory of Experimental Immunology and Virology,
Moscow
俄罗斯联邦参考
- Ilkovitch D., Ferris L. K. Myeloid-derived suppressor cells are elevated in patients with psoriasis and produce various molecules //Mol Med Rep,2016.14(4). рр3935–40.
- Козлов В. А. Клетки-супресоры – основа иммунопатогенеза аутоиммунных заболеваний // Медицинская иммунология, 2016. Т. 18, № 1. С. 7–14.
- Budhwar S., Verma P., Verma R., Rai S., Singh K. The Yin and Yang of Myeloid Derived Suppressor Cells // Front Immunol, 2018.Vol.9, p.2776.
- Lyadova I., Sosunova E., Nikolaev A., Nenasheva T. Mesenchymal Stem Cells and Myeloid Derived Suppressor Cells: Common Traits in Immune Regulation// Journal of Immunology Research, Vol. 2016, Article ID7121580, 17 p.
- Zhu J., Chen S., Wu L., Wang R., Zheng S., Zhao D., Wang X, Li J. The Expansion of Myeloid-Derived Suppressor Cells Is Associated with Joint Infl ammation in Rheumatic Patients with Arthritis // Bio Med Research International, Vol. 2018, Article ID5474828, 12 p.
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