LOCAL AND SYSTEMIC INFLAMMATORY REACTIONS AFTER IMPLANTATION OF DIFFERENT COMPOSITION SMALL DIAMETER VASCULAR GRAFTS

The most important criterion of implantable vascular prostheses biocompatibility is the intensity of local and systemic inflammatory reactions to the graft material. Purpose: To evaluate the intensity of local and systemic inflammatory reactions of the organism in the acute period after implantation of small diameter vascular prostheses created on the basis of different biodegradable polymers. Obtained by electrospinning biopolymer prosthesis were implanted in the abdominal aorta of rats: I - polycaprolactone (PCL); II - copolymer of polylactic acid/polycaprolactone (PLC 7015); III - copolymer of polylactic acid/ polycaprolactone with polyglycolide (PLC 7015-PGS); IV - polylactic acid/polycaprolactone (PL-18PCL); V - polycapro-lactone/polyglycolide (PCL-PGS); VI - sham-operated control group. Grafts explantation was performed on the 14th day. The intensity of the systemic inflammatory response was assessed by serum level of IL-6, IL-10 and MCP-1, the intensity of the local inflammatory reaction - by HE-stained grafts sections analyzing. Prosthesis implantation in all cases was accompanied by the local inflammatory reaction development that was most pronounced in the case of PL-18PCL and PCL-PGS. Elevated level of MCP-1 was observed only by PLC 7015 grafts implantation. All studied polymers could be used as a stock for small diameter vascular prostheses development.

биодеградируемые полимеры, сосудистые протезы, цитокины, воспалительная реакция, биосовместимость, biodegradable polymers, vascular grafts, cytokines, biocompatibility