FEATURES OF CONGENITAL IMMUNITY OF PREMATURE INFANTS WITH SEVERE HYPOXIC-ISCHEMIC LESIONS OF THE CENTRAL NERVOUS SYSTEM

With the purpose of revealing the features of the innate immunity of premature infants with severe hypoxic-ischemic injury of the central nervous system, depending on the gestational age, a survey of deeply preterm infants born at the time of very early and early premature births was conducted. It was established that in all premature infants with severe hypoxic-ischemic CNS lesions, the level of expression of adhesion molecules on monocytes (CD14+CD11b+) and an increase in the level of IFN-γ and IL-8 at birth was observed at birth, regardless of the gestational age. The peculiarity of the immune response of children born in the term of early premature births is a decrease in the relative number of activated monocytes of CD14+CD64+ and CD14+HLA-DR, which indicates a disruption in the relationship between the cells of congenital and adaptive immunity and may be the cause of bacterial complications and a prolonged course of inflammatory Process.

недоношенные дети, иммунитет, пуповинная кровь, гипоксически-ишемическое поражение центральной нервной системы, premature infants, immunity, umbilical cord blood, hypoxic-ischemic lesion of the central nervous system