电邮这篇文章 Polymorphism patterns of oxidative stress biomarker genes in Uzbek patients with acne
- 作者: Malikova N.N.1, Arifov S.S.1, Boboev K.T.2
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隶属关系:
- Center for Development of Professional Qualifications of Medical Workers
- Republican Specialized Scientific and Practical Medical Center of Hematology
- 期: 卷 28, 编号 6 (2025)
- 页面: 696-705
- 栏目: DERMATOLOGY
- URL: https://medbiosci.ru/1560-9588/article/view/367126
- DOI: https://doi.org/10.17816/dv687858
- EDN: https://elibrary.ru/OCCTMV
- ID: 367126
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详细
BACKGROUND: Inflammatory processes in acne are frequently accompanied by enhanced oxidative stress and reduced antioxidant activity, particularly of the enzyme superoxide dismutase.
AIM: This study aimed to analyze the influence of SOD2 gene polymorphic loci T58C (rs1141718), Ala16Val (rs4880), and C60T (rs11575993) in Uzbek patients with acne of varying severity.
METHODS: A case–control study was conducted using genomic DNA extracted from peripheral blood samples. The study lasted from February to December 2023. A total of 133 patients with acne were examined; the control group included 125 conditionally healthy Uzbek individuals without dermatologic or other diseases.
RESULTS: According to the Global Alliance to Improve Outcomes in Acne severity classification, patients were divided into three groups: mild acne (51; 38.3%), moderate acne (63; 47.4%), and severe acne (19; 14.3%). The unfavorable C allele and the T/C heterozygous genotype of rs1141718 were associated with a markedly increased risk of inflammation driven by oxidative stress; the risk was 8–13 times higher in patients with mild and severe acne (p < 0.05). Moreover, a clear trend toward a higher prevalence of the unfavorable Val allele was observed in the acne group, and the Val allele as well as the homozygous Val/Val genotype were found to be associated with greater clinical disease severity.
CONCLUSION: Polymorphic variants of genes related to oxidative stress biomarkers—particularly SOD2 (T58C, rs1141718; and Ala16Val, rs4880)—play an important role in the pathogenesis of oxidative stress in acne.
作者简介
Nilufar Malikova
Center for Development of Professional Qualifications of Medical Workers
编辑信件的主要联系方式.
Email: dr.malikova@gmail.com
ORCID iD: 0000-0001-6964-8372
SPIN 代码: 4972-0478
MD, Cand. Sci. (Medicine), doctoral student
乌兹别克斯坦, TashkentSaidkasim Arifov
Center for Development of Professional Qualifications of Medical Workers
Email: arifov1961@rambler.ru
ORCID iD: 0000-0001-7207-7283
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, TashkentKodirzhon Boboev
Republican Specialized Scientific and Practical Medical Center of Hematology
Email: saboboev@mail.ru
ORCID iD: 0000-0002-0297-1447
SPIN 代码: 2555-7212
MD, Dr. Sci. (Medicine), Professor
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