SUPPRESSIVE EFFECTS OF PSORALENE PHOTO-OXIDATION PRODUCTS ON CONTACT SENSITIVITY REACTION IN MICE: LYMPHOCYTE PROLIFERATION INHIBITION AND APOPTOSIS INDUCTION


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The effects of psoralene photo-oxidation products (PPP) on 2,4-dinitrofluorobenzene (DNFB) contact sensi tivity of mice were studied. Injections of PPP to DNFB-sensitized mice led to a decrease in the cell counts in the regional lymph nodes and to reduction of the cellular proliferative activity. Proliferation reduction was paralleled by changes in the lymph node cell cytokine balance: lesser production of IL-2, IL-4, and INF-γ and higher production of IL-17. Interestingly that PPP did not change the production of IL-10 and IL-6 by the lymph node cells in vivo. In vitro incubation of the lymph node cells of DNFB-sensitized mice with PPP led to induction of these cells’ apoptosis. It seemed that modulation of the lymphocyte cytokine profile under lay the mechanism of PPP immunosuppressive activity, this leading to reduction of these cells’ proliferative activity and apoptosis induction.

作者简介

Ilya Pyatnitsky

N.I.Pirogov National Research Medical University

аспирант

Svetlana Pavlova

D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology; I.N.Ulyanov Chuvash State University

доктор мед. наук, профессор

Diana Albegova

N.I.Pirogov National Research Medical University

кандидат мед. наук, доцент

Ivan Kozlov

N.I.Pirogov National Research Medical University; D. Rogachev Federal Research and Clinical Center of Pediatric Hematology, Oncology, and Immunology

доктор мед. наук, профессор

Aleksandr Potapenko

N.I.Pirogov National Research Medical University

доктор биол. наук, профессор

Alla Kyagova

N.I.Pirogov National Research Medical University

Email: kyagova.alla@gmail.com
доктор мед. наук, профессор

参考

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