Array-based comparative genomic hybridization (ARRAY-CGH) in analysis of chromosomalaberrations and CNV in blighted ovum pregnancies

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Application of modern molecular cytogenetic technologies in research and clinical practice provides unprecedented possibilities for high resolution molecular karyotyping in different areas of clinical cytogenetics. In this study the oligonucleotide-based array-CGH data about unbalanced chromosomal aberrations and copy number variations (CNV) in blighted ovum pregnancies are presented. Analysis of genes content of involved chromosomal regions was done. Scopes, perspectives and limitations of aCGH application into analysis of early pregnancy losses are discussed.

作者简介

Igor Lebedev

Institute of Medical Genetics SB RAMS

Email: igor.lebedev@medgenetics.ru
Doctor of Biological Sciences, Head of Laboratory of Cytogenetics

Anna Kashevarova

Institute of Medical Genetics SB RAMS

Email: anna.kashevarova@medgenetics.ru
PhD, researcher of Laboratory of Cytogenetics

Nikolay Skryabin

Institute of Medical Genetics SB RAMS

Email: skryabinn@mail.ru
PhD, researcher of Laboratory of Cytogenetics

Tatyana Nikitina

Institute of Medical Genetics SB RAMS

Email: tatyana.nikitina@medgenetics.ru
PhD, researcher of Laboratory of Cytogenetics

Mariya Lopatkina

Institute of Medical Genetics SB RAMS

PhD, researcher of Laboratory of Cytogenetics

Aleksandr Melnikov

Institute of Medical Genetics SB RAMS

Email: genetic87@sibmail.com
PhD, researcher of Laboratory of Cytogenetics

Yelena Sazhenova

Institute of Medical Genetics SB RAMS

Email: elena.sazhenova@medgenetics.ru
PhD, researcher of Laboratory of Cytogenetics

Tatyana Ivanova

Siberian State Medical University

Email: itv7@yandex.ru
PhD, Associate professor of Chair of Obstetrics and Gynecology

Irina Yevtushenko

Siberian State Medical University

Email: evtushenko_id@mail.ru
MD, Professor, Head of Chair of Obstetrics and Gynecology

参考

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版权所有 © Lebedev I.N., Kashevarova A.A., Skryabin N.A., Nikitina T.V., Lopatkina M.Y., Melnikov A.A., Sazhenova Y.A., Ivanova T.V., Yevtushenko I.D., 2013

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