Light regimen, anovulation, and risk of malignant neoplasms of the female reproductive system:the mechanisms of link and prevention

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This article contains own and literature data on stimulating influence of constant light illumination on the risk of the development of anovulation, hyperplastics processes and cancers of the female reproductive system organs (mammary gland, endometrium, and ovaries) in the laboratory animals and women. Contrary, the light deprivation obstacles to the cancer development. The ata on the key role of the inhibition of production of pineal hormone melatonin in the pathology that developed under the effect of light-at-night as well as on the possible prevention of this pathology with melatonin and pineal peptides are reported.

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V. Anisimov

Research Institute of Oncology named after prof. N. N. Petrova M3 RF

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Email: info@eco-vector.com

Department of Carcinogenesis and Oncogerontology

俄罗斯联邦, Saint Petersburg

Eduard Ailamazyan

Saint Petersburg State Medical University named after acad. I. P. Pavlova

Email: info@eco-vector.com

Professor

俄罗斯联邦, Saint Petersburg

D. Baturin

Research Institute of Oncology named after prof. N. N. Petrova M3 RF; Saint Petersburg State Medical University named after acad. I. P. Pavlova

Email: info@eco-vector.com

Department of Carcinogenesis and Oncogerontology

俄罗斯联邦, Saint Petersburg; Saint Petersburg

М. Zabezhinsky

Research Institute of Oncology named after prof. N. N. Petrova M3 RF

Email: info@eco-vector.com

Department of Carcinogenesis and Oncogerontology

俄罗斯联邦, Saint Petersburg

I. Alimova

Research Institute of Oncology named after prof. N. N. Petrova M3 RF

Email: info@eco-vector.com

Department of Carcinogenesis and Oncogerontology

俄罗斯联邦, Saint Petersburg

I. Popovich

Research Institute of Oncology named after prof. N. N. Petrova M3 RF

Email: info@eco-vector.com

Department of Carcinogenesis and Oncogerontology

俄罗斯联邦, Saint Petersburg

D. Beniashvily

Institute of Pathology, Medical Center E. Wolfson

Email: nfo@eco-vector.com
以色列, Holon

K. Menton

Duke University

Email: nfo@eco-vector.com
美国, Durham, North Carolina

M. Provincialy

National Center for Research on Aging

Email: nfo@eco-vector.com
意大利, Ancona

K. Franchesky

National Center for Research on Aging

Email: nfo@eco-vector.com
意大利, Ancona

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2. Fig. 1. Change in the incidence of breast cancer (BC) (standardized indicator) in women depending on geographical latitude

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3. Fig. 2. Change in the incidence of breast cancer (BC) (standardized indicator) in women, depending on the region of Russia

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4. Fig. 3. Dynamics of the increase in the number of mammary gland tumors (BMT) in female HER-2 / neu mice

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5. Fig. 4. Influence of the illumination regime on the frequency (A) and mean latent period (B) of tumors in rats caused by transplacental administration of N-nitrosoethylurea

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6. Fig. 5. Effect of melatonin, epitalon, and vilon on the expression of the HER-2 / neu oncogene in mammary tumors in transgenic mice (Baturin et al., 2001; Anisimov et al., 2002)

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