Hepatitis A virus seroprevalence in Kyrgyzstan

Cover Image

Cite item

Full Text

Abstract

Introduction. Kyrgyzstan, among other Central Asian countries, is one of the highly endemic regions for hepatitis A. An important tool for assessing the true burden of these infections on the population and the success of ongoing prevention programs is to study the prevalence of markers of past and current hepatitis A in all age groups of the population, as well as the intensity of population immunity to this virus in regions with different morbidity.

Aim. To study the hepatitis A virus (HAV) seroprevalence among residents of the Kyrgyzstan regions.

Materials and methods. Blood serum samples from conditionally healthy individuals (n = 2297) who sought medical attention at medical institutions in Bishkek, Batken, Chüy, Jalal-Abad, Issyk-Kul, Osh, Talas and Naryn regions. IgM and IgG antibodies to hepatitis A virus (anti-HAV IgM, anti-HAV IgG) were determined using the «Vectohep A-IgM» and «Vectohep A-IgG» (Vector-Best) enzyme immunoassay kits. Statistical processing of the results was carried out using Excel and Medcalc programs.

Results. 80.3% of the studied samples contained HAV serologic markers, of which 80.3% contained anti-HAV IgG antibodies and 4.7% contained anti-HAV IgM antibodies. All IgM-positive samples contained specific IgG antibodies. Such samples were identified with the same frequency among women and men. The highest seropositivity rates were observed in the age groups 30–39, 40–49, and 50–59 years. The number of individuals with anti-HAV IgG antibodies in their blood serum increased with their age. An analysis of the immunostructure of the examined individuals by the level of anti-HAV IgG in serum showed relatively stable ratios of low, medium and high levels of antibodies in groups older than 30 years. The most frequently anti-HAV IgM and IgG antibodies were detected in samples from residents of Bishkek. Anti-HAV IgG antibodies were detected in samples from all surveyed regions of Kyrgyzstan, while anti-HAV IgM antibodies were identified in samples from Chüy, Issyk-Kul and Osh regions, as well as Bishkek.

Conclusion. Hepatitis A remains widespread in Kyrgyzstan. The determination of HAV seromarkers in the algorithms of complex hepatitis diagnostics and seroepidemiological studies remains relevant. A decrease in the level of population immunity to HAV in younger age group indicates the country's transition from high to medium endemicity, which suggests an increase in the number of clinically pronounced cases in the future in the absence of a hepatitis A vaccination program for children.

About the authors

Galina I. Alatortseva

I. Mechnikov Research Institute for Vaccines and Serа

Author for correspondence.
Email: alatortseva@gmail.com
ORCID iD: 0000-0001-9887-4061

Cand. Sci. (Biol.), leading researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Lyudmila N. Pritvorova

I. Mechnikov Research Institute for Vaccines and Serа

Email: lexx294@yandex.by
ORCID iD: 0000-0002-2997-8892

Cand. Sci. (Med.), leading researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Zuridin Sh. Nurmatov

National Institute of Public Health

Email: logvinenko.nurmatov@gmail.com
ORCID iD: 0000-0003-3481-227X

Dr. Sci. (Med.), Head, Republican Scientific and Practical Center for Viral Infection Control

Kyrgyzstan, Bishkek

Lyubov N. Nesterenko

I. Mechnikov Research Institute for Vaccines and Serа

Email: lnnesterenko3001@gmail.com
ORCID iD: 0000-0002-3825-3906

Cand. Sci. (Chem.), leading researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Vera V. Dotsenko

I. Mechnikov Research Institute for Vaccines and Serа

Email: verramal@gmail.com
ORCID iD: 0000-0002-5866-944X

Cand. Sci. (Biol.), senior researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Vera Yu. Kabargina

I. Mechnikov Research Institute for Vaccines and Serа

Email: v.cabargina@yandex.ru
ORCID iD: 0000-0002-8784-4497

researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Irina I. Amiantova

I. Mechnikov Research Institute for Vaccines and Serа

Email: amianti@yandex.ru
ORCID iD: 0000-0003-3483-0128

researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Marina V. Zhukina

I. Mechnikov Research Institute for Vaccines and Serа

Email: dwesome.zhukina@gmail.com
ORCID iD: 0000-0002-2329-5089

researcher, Laboratory of viral genomes cloning, Department of virology named after O.G. Andzhaparidze

Russian Federation, Moscow

Zamira O. Abdrakhmanova

National Institute of Public Health

Email: abdrahmanova.z@list.ru
ORCID iD: 0000-0002-2645-863X

epidemiologist

Kyrgyzstan, Bishkek

Uulkan S. Karatayeva

Kyrgyz State Medical Institute for Retraining and Advanced Training named after S.B. Daniyarova

Email: u.karataeva@list.ru
ORCID iD: 0009-0009-0252-2690

Head, Interfaculty department of public health, with a course of infection control

Kyrgyzstan, Osh

Karen K. Kyuregyan

I. Mechnikov Research Institute for Vaccines and Serа; Central Research Institute of Epidemiology

Email: karen-kyuregyan@yandex.ru
ORCID iD: 0000-0002-3599-117X

Dr. Sci. (Med.), Professor of RAS, leading researcher, I. Mechnikov Research Institute for Vaccines and Sera; Head, Laboratory of molecular diagnostics of viral hepatitis, Central Research Institute of Epidemiology

Russian Federation, Moscow; Moscow

Mikhail I. Mikhailov

I. Mechnikov Research Institute for Vaccines and Serа; Central Research Institute of Epidemiology

Email: michmich2@yandex.ru
ORCID iD: 0000-0002-6636-6801

Dr. Sci. (Med.), Professor, RAS Full Member, Head, Laboratory for viral hepatitis, I. Mechnikov Research Institute for Vaccines and Sera, chief researcher, Central Research Institute of Epidemiology

Russian Federation, Moscow; Moscow

Vitaly V. Zverev

I. Mechnikov Research Institute for Vaccines and Serа

Email: vitalyzverev@outlook.com
ORCID iD: 0000-0002-0017-1892

Dr. Sci. (Biol.), Professor, RAS Full Member, Head, chief researcher

Russian Federation, Moscow

Oxana A. Svitich

I. Mechnikov Research Institute for Vaccines and Serа

Email: svitichoa@yandex.ru
ORCID iD: 0000-0003-1757-8389

D. Sci. (Med.), RAS Full Member, Director

Russian Federation, Moscow

References

  1. Абдикаримов С.Т. Эпидемиологические особенности инфекций, передающихся водным путем в Кыргызской республике. Бишкек;2013. Abdikarimov S.T. Epidemiological Features of Water-Borne Infections in the Kyrgyz Republic. Bishkek;2013.
  2. Усманов Р.К. Эпидемические и вирусологические закономерности вирусных гепатитов на примере Кыргызской республики: Автореф. дисс. … д-ра мед. наук. М.;1995. Usmanov R.K. Epidemiological and virological patterns of viral hepatitis on the example of the Kyrgyz Republic: Diss. Moscow;1995.
  3. Абдрахманова З.О., Суранбаев С.Т., Нурматов З.Ш. Сезонность вирусного гепатита А в Кыргызской Республике. Здравоохранение Кыргызстана. 2024;(1):35–40. Abdrakhmanova Z.O., Nurmatov Z.Sh., Suranbaev S.T. Seasonality of viral hepatitis A in the Kyrgyz Republic. Health Care of Kyrgyzstan Scientific and Practical Journal. 2024;(1):35–40. DOI: https://doi.org/10.51350/zdravkg2024.1.3.4.35.40
  4. Петров В.И., Рязанова А.Ю. Базовые статистические знания, необходимые для интерпретации современных данных клинических исследований. Лекарственный вестник. 2021;15(1):3–11. Petrov V.I., Ryazanova A.Yu. Basic statistical knowledge necessary for the interpretation of modern clinical research data. Drug Bulletin. 2021;15(1):3–11. EDN: https://elibrary.ru/czxdvu
  5. Малышев В.В. Вирусные гепатиты А и Е: вопросы эпидемиологии, специфической диагностики и профилактики. В кн.: Кузин А.А., ред. От теории саморегуляции к мировой самоизоляции: современные вызовы эпидемиологической науке и практике: Сборник статей Всероссийской межведомственной научно-практической конференции. СПб.;2022:135–40. Malyshev V.V. Viral hepatitis A and E: issues of epidemiology, specific diagnostics and prevention. In: Kuzin A.A., ed. From the Theory of Self-Regulation to Global Self-Isolation: Modern Challenges to Epidemiological Science and Practice: Collection of Articles of the All-Russian Interdepartmental Scientific and Practical Conference. St. Petersburg;2022:135–40. https://elibrary.ru/gqkxms
  6. Мукомолов С.Л., Сталевская А.В., Железнова Н.В., Левакова И.А. Некоторые особенности эпидемического процесса гепатита А, определяющие стратегии профилактики и контроля этой инфекции на современном этапе. Вопросы современной педиатрии. 2011;10(3):131–6. Mukomolov S.L., Stalevskaya A.V., Zheleznova N.V., Levakova I.A. Peculiarities of hepatitis a epidemic process, that determine modern prophylaxis and infection control strategies. Current Pediatrics. 2011;10(3):131–6. EDN: https://elibrary.ru/nxlkzr
  7. Кареткина Г.Н. Вирусный гепатит А в прошлом, настоящем и будущем. Инфекционные болезни: новости, мнения, обучение. Журнал имени академика Н.Д. Ющука. 2014;(3):38–48. Karetkina G.N. Viral hepatitis A: past, present and future. Infectious Diseases: News, Opinions, Training. Journal Named after Academician N.D. Yushchuk. 2014;(3):38–48. EDN: https://elibrary.ru/tdoxtb
  8. Джангазиева А.А., Кутманова А.З., Касымова Р.О., Саттарова Г.Ж. Эпидемиологическая характеристика вирусного гепатита А в Кыргызской Республике за период с 2000 г. по 2014 г. Международный журнал прикладных и фундаментальных исследований. 2015;(12-1):68–72. Dzhangazieva A.A., Kutmanova A.Z., Kasymovа R.O., Sattarova G.J. Epidemiological characteristics of viral hepatitis a in the Kyrgyz Republic for 2000–2014 years. International Journal of Applied and Fundamental Research. 2015;(12-1):68–72. EDN: https://elibrary.ru/uwpmwx
  9. Mun E., Lee Y., Suh B., et al. Factors associated with anti-hepatitis A virus immunoglobulin G seropositivity among Korean workers: a cross-sectional study. BMJ Open. 2020;10(6):e036727. DOI: https://doi.org/10.1136/bmjopen-2019-036727
  10. Каира А.Н., Свитич О.А. Особенности эпидемического процесса вирусных гепатитов А и Е в Российской Федерации. Эпидемиология и Вакцинопрофилактика. 2021;20(5):69–78. Kaira A.N., Svitich O.A. Features of the epidemic process of viral hepatitis A and E in the Russian Federation. Epidemiology and Vaccinal Prevention. 2021;20(5):69–78. DOI: https://doi.org/10.31631/2073-3046-2021-20-4-69-78 EDN: https://elibrary.ru/cztmyq

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Alatortseva G.I., Pritvorova L.N., Nurmatov Z.S., Nesterenko L.N., Dotsenko V.V., Kabargina V.Y., Amiantova I.I., Zhukina M.V., Abdrakhmanova Z.O., Karatayeva U.S., Kyuregyan K.K., Mikhailov M.I., Zverev V.V., Svitich O.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).