Method for Producing 5-Cyano-2-Methyl-n-(2-Methylphenyl)-4-(4-Nitrophenyl)-6-Thioxo-1,6-Dihydropyridine-3-Carboxamide Derivatives

封面

如何引用文章

全文:

开放存取 开放存取
受限制的访问 ##reader.subscriptionAccessGranted##
受限制的访问 订阅存取

详细

The multicomponent interaction of 4-nitrobenzaldehyde, cyanothioacetamide, N-(2-methylphenyl)-3-oxobutanamide and alkyl halides upon boiling in ethanol in the presence of twice the amount of potassium hydroxide produced derivatives of 5-cyano-2-methyl-N-(2-methylphenyl)-4-(4-nitrophenyl)-6-thioxo-1,6-dihydropyridine-3-carboxamide – 2-alkylthiopyridines and 3-aminothieno[2,3-b]pyridines, with yields of 64–91%.

作者简介

B. Krivokolysko

V. Dahl Lugansk State University; St. Luke Lugansk State Medical University

ORCID iD: 0000-0002-3181-7609
Chemex Lab Lugansk, Russia; Lugansk, Russia

D. Nikitenko

Institute of Physical Organic Chemistry and Coal Chemistry

ORCID iD: 0000-0001-6902-8114
Donetsk, Russia

S. Krivokolysko

V. Dahl Lugansk State University; St. Luke Lugansk State Medical University

Email: ksg-group-lugansk@mail.ru
ORCID iD: 0000-0001-9879-9217
Chemex Lab Lugansk, Russia; Lugansk, Russia

参考

  1. Lukevits E. Chem. Heterocycl. Compd. 1995, 31 (6), 639–650. https://doi.org/10.1007/BF01169065
  2. Vitaku E., Smith D.T., Njardarson J.T. J. Med. Chem. 2014, 57 (24), 10257–10274. https://doi.org/10.1021/jm501100b
  3. Khamitova A.E., Berillo D.A. Drug Develop. Registr. 2023, 12 (2), 44–54. https://doi.org/10.33380/2305-2066-2023-12-2-4454
  4. De la Torre B.G., Albericio F. Molecules. 2022, 27 (3), 1075. https://doi.org/10.3390/molecules27031075
  5. Salem M.A., Helel M.H., Gouda M.A., Ammar Y.A., El-Gaby M.S.A. Synth. Commun. 2018, 48 (4), 345–374. https://doi.org/10.1080/00397911.2017.1394468
  6. Gouda M.A., Hussein B.H., Helal M.H., Salem M.A. J. Heterocycl. Chem. 2018, 55 (7), 1524–1553. https://doi.org/10.1002/jhet.3188
  7. Khan M.M., Khan S., Iqbal S. RSC Adv. 2016, 48 (6), 42045–42061. https://doi.org/10.1039/c6ra06767k
  8. Gouda M.A., Berghot M.A., Abd El Ghani G.E., Khalil A.E.G.M. Synth. Commun. 2014, 44 (3), 297–330. https://doi.org/10.1080/00397911.2013.823549
  9. Litvinov V.P. Russ. Chem. Rev. 2006, 75 (7), 577–599. https://doi.org/10.1070/RC2006v075n07ABEH003619
  10. Dyachenko V.D., Krivokolysko S.G., Nesterov V.N., Litvinov V.P. Chem. Heterocycl. Compd. 1996, 32 (9), 1066–1074. https://doi.org/10.1007/BF01164714
  11. Dyachenko V.D., Krivokolysko S.G., Litvinov V.P. Chem. Heterocycl. Compd. 1996, 32 (9), 1055–1057. https://doi.org/10.1007/BF01164712
  12. Elgemeie G.H., Eltamny E.H., Elgawad I.I., Mahmoud N.M. Synth. Commun. 2009, 39 (3), 443–458. https://doi.org/10.1080/00397910802379199
  13. Rodinovskaya L.A., Gromova V.A., Shestopalov A.M., Nesterov V.N. Russ. Chem. Bull. 2003, 52 (10), 2207–2213. https://doi.org/10.1023/B:RUCB.0000011880.05561.c1
  14. Rodinovskaya L., Shestopalov A., Gromova A., Shestopalov A. Synthesis. 2006, 14, 2357–2370. https://doi.org/10.1055/s-2006-942433
  15. Dyachenko V.D. Russ. J. Gen. Chem. 2005, 75 (3), 447–456. https://doi.org/10.1007/s11176-005-0248-4
  16. Dyachenko V.D., Chernega A.N. Chem. Heterocycl. Compd. 2006, 42 (1), 45–52. https://doi.org/10.1007/s10593-006-0045-y
  17. Elgemeie G.H., Fathy N.M., Farag A.B., Alkursani Sh.A. Nucleosid. Nucleotid. Nucleic Acids. 2017, 36 (5), 355–377. https://doi.org/10.1080/15257770.2017.1297454
  18. Dyachenko I.V., Dyachenko V.D., Dorovatovskiy P.V., Khrustalev V.N., Nenaidenko V.G. Russ. J. Gen. Chem. 2024, 94 (6), 1217–1230. https://doi.org/10.1134/S107036322406001X
  19. Dyachenko I.V., Kalashnik I.N., Dyachenko V.D., Dorovatovskii P.V., Khrustalev V.N., Nenajdenko V.G. Russ. J. Org. Chem. 2019, 55 (7), 1019–1033. https://doi.org/10.1134/s1070428019070194
  20. Mullan M.J., Paris D., Bakshi P. Patent Roskamp Research LLC. WO2008/70875 (2008).
  21. Osolodkin D.I., Kozlovskaya L.I., Dueva E.V., Dotsenko V.V., Rogova Yu.V., Frolov K.A., Krivokolysko S.G., Romanova E.G., Morozov A.S., Karganova G.G., Palyulin V.A., Pentkovski V.M., Zefirov N.S. ACS Med. Chem. Lett. 2013, 4 (9), 869–874. https://doi.org/10.1021/ml400226s
  22. Dyachenko I.V., Dyachenko V.D., Dorovatovskii P.V., Khrustalev V.N., Nenajdenko V.G. Chem. Heterocycl. Compd. 2019, 55 (4–5), 442–447. https://doi.org/10.1007/s10593-019-02477-7

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Russian Academy of Sciences, 2025

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).