The Sublimate Production Cohort of the Siberian Chemical Plant (Dosimetric Characteristics)
- Authors: Kalinkin D.E.1,2, Milto I.V.1,2, Takhauov A.R.1, Takhauova L.R.1,2, Samoilova Y.A.3, Gorina G.V.1, Litvinova O.V.1, Takhauov R.M.1,2
-
Affiliations:
- Seversk Biophysical Research Center
- Siberian State Medical University
- Siberian Federal Scientific Clinical Center
- Issue: Vol 69, No 1 (2024)
- Pages: 73-76
- Section: Radiation Epidemiology
- URL: https://medbiosci.ru/1024-6177/article/view/363903
- DOI: https://doi.org/10.33266/1024-6177-2024-69-1-73-76
- ID: 363903
Cite item
Full Text
Abstract
Introduction: Uranium, which is the raw material basis of the nuclear industry, is capable of causing adverse medical and biological consequences for workers who come into contact with its compounds in the course of their professional activities. In order to study this effect and to study in detail the biomedical consequences of the effects of uranium compounds on the body of personnel of nuclear power facilities, it is necessary to form a cohort of persons engaged in work with uranium compounds. One of the key elements of the uranium conversion technology carried out within the framework of sublimation production is the production of raw uranium hexafluoride for subsequent isotopic enrichment.
Purpose: To form and characterize a cohort of sublimate production of the personnel of the Siberian Chemical Plant involved in work with uranium compounds in the period 1953–2000.
Material and methods: The source of information was the regional medical dosimetric register of Seversk Biophysical Research Center, containing information on all current and former employees of the Siberian Chemical Plant (about 65,000 people) from the moment of the company’s foundation to the present.
Results: A cohort of Siberian Chemical Plant workers involved in work with uranium compounds in the period 1953–2000 has been formed and described. The cohort consists of 577 people (475 men and 102 women). Biomedical information and dosimetric information about the employees included in the cohort are included in the created database of the personnel of the Siberian Chemical Plant involved in working with uranium compounds in the period 1953–2000.
Conclusion: The formed cohort and database will allow conducting epidemiological studies to assess the morbidity and mortality of personnel due to malignant neoplasms, as well as making scientifically sound conclusions about the role of uranium compounds in the occurrence and mortality due to malignant neoplasms.
About the authors
D. E. Kalinkin
Seversk Biophysical Research Center; Siberian State Medical University
Author for correspondence.
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk; Tomsk
Ivan V. Milto
Seversk Biophysical Research Center; Siberian State Medical University
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk; Tomsk
Anas R. Takhauov
Seversk Biophysical Research Center
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk
Lilia R. Takhauova
Seversk Biophysical Research Center; Siberian State Medical University
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk; Tomsk
Yulia A. Samoilova
Siberian Federal Scientific Clinical Center
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk
Galina V. Gorina
Seversk Biophysical Research Center
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk
Olesya V. Litvinova
Seversk Biophysical Research Center
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk
Ravil M. Takhauov
Seversk Biophysical Research Center; Siberian State Medical University
Email: mail@sbrc.seversk.ru
Russian Federation, Seversk; Tomsk
References
- Surdyk S., Itani M., Al-Lobaidy M., Kahale L.A., Farha A., Dewachi O., Akl E.A., Habib R.R. Weaponised Uranium and Adverse Health Outcomes in Iraq: a Systematic Reviewю BMJ Glob. Health. 2021;6;2:e004166. doi: 10.1136/bmjgh-2020-004166.
- Tirmarche M., Apostoaei I., Blanchardon E., Ellis E.D., Gilbert E., Harrison J.D., Laurier D., Marsh J.W., Sokolnikov M., Wakeford R., Zhivin S. ICRP Publication 150: Cancer Risks from Plutonium and Uranium Exposure. Ann. ICRP. 2021;50;4:1–143. doi: 10.1177/01466453211028020.
- Tomasek L. Lung Cancer Lifetime Risks in Cohort Studies of Uranium Miners. Radiat. Prot. Dosimetry. 2020;191;2:171–175. doi: 10.1093/rpd/ncaa143.
- Thandra K.C., Barsouk A., Saginala K., Aluru J.S., Barsouk A. Epidemiology of Lung Cancer // Contemp Oncol (Pozn). 2021;25;1:45–52. doi: 10.5114/wo.2021.103829.
- Kelly-Reif K., Sandler D.P., Shore D., Schubauer-Berigan M.K., Troester M.A., Nylander-French L., Richardson D.B. Radon and Cancer Mortality among Underground Uranium Miners in the Příbram Region of the Czech Republic. Am. J. Ind. Med. 2020;63;10:859–867. doi: 10.1002/ajim.23167.
- da Silva F.M.R. Júnior, Tavella R.A., Fernandes C.L.F., Dos Santos M. Genetic Damage in Coal and Uranium Miners. Mutat. Res. Genet. Toxicol. Environ Mutagen. 2021;866:503348. doi: 10.1016/j.mrgentox.2021.503348.
- Golden A.P., Milder C.M., Ellis E.D., Anderson J.L., Boice Jr J.D., Bertke S.J., Zablotska L.B. Cohort Profile: four Early Uranium Processing Facilities in the US and Canada. Int. J. Radiat. Biol. 2021;97;6:833–847. doi: 10.1080/09553002.2021.1917786.
- Semenova Y., Pivina L., Zhunussov Y., Zhanaspayev M., Chirumbolo S., Muzdubayeva Z., Bjørklund G. Radiation-Related Health Hazards to Uranium Miners. Environ Sci. Pollut. Res. Int. 2020;27;28:34808–34822. doi: 10.1007/s11356-020-09590-7.
- Richardson D.B., Rage E., Demers P.A., Do M.T., Fenske N., Deffner V., Kreuzer M., Samet J., Bertke S.J., Kelly-Reif K., Schubauer-Berigan M.K., Tomasek L., Zablotska L.B., Wiggins C., Laurier D. Lung Cancer and Radon: Pooled Analysis of Uranium Miners Hired in 1960 or Later. Environ Health Perspect. 2022;130;5:57010. doi: 10.1289/EHP10669.
- Rage E., Richardson D.B., Demers P.A., Do M.T., Fenske N., Kreuzer M., Samet J., Wiggins C., Schubauer-Berigan M.K., Kelly-Reif K., Tomasek L., Zablotska L.B., Laurier D. PUMA – Pooled Uranium Miners Analysis: Cohort Profile. Occup. Environ Med. 2020;77;3:194–200. doi: 10.1136/oemed-2019-105981.
Supplementary files

