Analysis of the Incidence of Solid Malignant Neoplasms in the Urals Cohort of Exposed Population Offspring
- Authors: Zavyalov D.A.1, Krestinina L.Y.1
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Affiliations:
- Ural Research Center for Radiation Medicine
- Issue: Vol 69, No 6 (2024)
- Pages: 51-55
- Section: Radiation Epidemiology
- URL: https://medbiosci.ru/1024-6177/article/view/363962
- DOI: https://doi.org/10.33266/1024-6177-2024-69-6-51-55
- ID: 363962
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Abstract
Purpose: The study of regularities in the incidence of solid cancer in the Urals Cohort of the Exposed Population Offspring over a 65-year follow-up period.
Material and methods: The study was conducted by cohort method. The cohort under study is the Urals Cohort of the Exposed Population Offspring. It includes offspring of the population exposed in the period from 1950 to 1960 in the Southern Urals (on the Techa River and at the East Urals radioactive trace). The catchment area includes 5 districts of the Chelyabinsk region, as well as the city of Chelyabinsk and the city of Ozyorsk. The follow-up period was 65 years, from 01.01.1956 to 31.12.2020, the number of the analytical cohort for 2024 is 24952 people, the number of person-years under follow-up is 850698. Calculation of cases, incidence rates, person-years and statistical processing of data were performed by standard methods using the DATAB program module of the Epicure statistical package.
Results: During the 65-year period, 569 cases of solid cancers were registered in the catchment area. In women the most frequent cases were neoplasms of female reproductive organs, breast, thyroid gland, whole intestine and upper digestive tract organs; in men - respiratory organs, upper digestive tract and whole intestine. A significant increase in the incidence rates was found in women in age groups older than 20 years and in men in groups older than 30 years. Statistically significant sex-depended differences were observed only in the age groups between 30 and 50 years. No significant differences in the incidence rates among offspring of different ethnic groups were found. An assessment of incidence rates by calendar periods was carried out: in women, a significant increase in incidence rates began in 1990, in men in 2005 and significant differences by sex were observed only in the period from 2005 to 2020.
Conclusion: The study revealed patterns in the incidence of solid malignant neoplasms within the offspring cohort by sex, age and depending on the calendar period. These patterns will be taken into account in future studies when assessing the dependence of the incidence of solid malignant neoplasms in offspring on parental gonadal dose.
About the authors
D. A. Zavyalov
Ural Research Center for Radiation Medicine
Email: dan.zavyalov2012@gmail.com
Chelyabinsk
L. Yu. Krestinina
Ural Research Center for Radiation Medicine
Email: dan.zavyalov2012@gmail.com
Chelyabinsk
References
- Sosnina S.F., Sokolnikov M.E. Heritable Effects in Offspring Associated with Harmful Exposure to Parents (Literature Review). Radiatsionnaya Gygiena = Radiation Hygiene. 2019;12;3:84-95 (In Russ.) doi: 10.21514/1998-426X-2019-12-3-84-95.
- UNSCEAR. Sources, Effects and Risks of Ionizing Radiation. UNSCEAR 2013 Report. Volume II. Scientific Annex B: Effects of Radiation Exposure of Children. New York, 2013. 284 p.
- Dubrova Yu.E. Mutation Induction in the Mouse and Human Germline. Russian Journal of Genetics. 2016 Jan;52(1):17–28. doi: 10.1134/s1022795416010038 (In Russ.).
- Oslina DS, Rybkina VL, Azizova TV. Transmission of Radiation-Induced Genome Instability from Irradiated Parents to their Offspring. MEDICAL RADIOLOGY AND RADIATION SAFETY. 2022 Aug;67(4):10–8 (In Russ.). doi: 10.33266/1024-6177-2022-67-4-10-18.
- Ozasa K, Cullings HM, Ohishi W, Hida A, Grant EJ. Epidemiological Studies of Atomic Bomb Radiation at the Radiation Effects Research Foundation. International Journal of Radiation Biology. 2019 Feb 1;95(7):879–91. doi: 10.1080/09553002.2019.1569778
- Kochergina EV, Gorski AI, Chekin SYu, Korelo AM, Tumanov KA, Zelenskaya NS, et al. General Morbidity among Children of Chernobyl Cleanup Workers: Radiation Epidemiological Study. Radiation and Risk. Bulletin of the National Radiation and Epidemiological Registry. 2021;30(1):110–30 (In Russ.). doi: 10.21870/0131-3878-2021-30-1-110-130
- Sosnina SF, Okatenko PV. Consequences of Maternal Preconceptional Exposure: Solid Cancers in Offspring in the First Generation. Radiation and Risk. Bulletin of the National Radiation and Epidemiological Registry. 2019;28(3):132–44 (In Russ.). doi: 10.21870/0131-3878-2019-28-3-132-144.
- Krestinina LYu, Shalaginov SA, Startsev NV. Urals Cohort of Exposed Population Offspring. Voprosy Radiatsionnoy Bezopasnosti = Issues of Radiation Safety. 2022;4(108):86-94 (In Russ.)
- Degteva MO, Napier BA, Tolstykh EI, Shishkina EA, Shagina NB, Volchkova AYu, et al. Enhancements in the Techa River Dosimetry System: Trds-2016d code for Reconstruction of Deterministic Estimates of Dose from Environmental Exposures. Health Physics. 2019 Apr 8;117(4):378–87. doi: 10.1097/hp.0000000000001067.
- Posledstviya Radioaktivnogo Zagryazneniya Reki Techi = Consequences of Radioactive Contamination of the Techa River. Ed. Akleyev A.V. Chelyabinsk, Kniga Publ., 2016. 400 p. (In Russ).
- Preston D.L., Lubin J.H., Pierce D.A., McConney M.E. Epicure Users Guide. Seattle, Washington: Hirosoft International Company, 1993.
- Kaprin A.D., Starinskiy V.V., Petrova G.V. Zlokachestvennyye Novoobrazovaniya v Rossii v 2014 Godu (Zabolevaemost’ I Smertnost’) = Malignant Neoplasms in Russia in 2014 (Morbidity and Mortality). Moscow Publ., 2016. 250 p. (In Russ.).
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