Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, Cd) in patients with two pathologies, lymphoma and leukemia, is considered.

About the authors

V. A. Trunova

Nikolaev Institute of Inorganic Chemistry SB RAS; Novosibirsk State University

Email: valna-t@mail.ru
Novosibirsk, 630090 Russia; Novosibirsk, 630090 Russia

T. I. Pospelova

Novosibirsk State Medical University

Novosibirsk, 630091 Russia

M. S. Voytko

Novosibirsk State Medical University

Novosibirsk, 630091 Russia

E. S. Krupovich

Nikolaev Institute of Inorganic Chemistry SB RAS; SRF “SKIF”, Institute of Catalysis SB RAS

Novosibirsk, 630090 Russia; Novosibirsk region, Koltsovo settlement, 630559 Russia

G. S. Soldatova

Novosibirsk State Medical University; Novosibirsk State University

Novosibirsk, 630091 Russia; Novosibirsk, 630090 Russia

R. O. Kuzmin

Novosibirsk State Medical University

Novosibirsk, 630091 Russia

K. S. Tsigulev

Novosibirsk State Medical University

Novosibirsk, 630091 Russia

References

  1. Овечкина В.Н., Бондаренко С.Н., Морозова Е.В. и др. // Клиническая онкогематология. 2017. T. 10 № 3. C. 351. http://doi/org/10.21320/2500-2139-2017-10-3-351-357
  2. Schmid C., Labopin M., Nagler A., Niederwieser D., Castagna L., Tabrizi R., Stadler M., Kuball J., Cornelissen J., Vorlicek J., Socié G., Falda M., Vindeløv L., Ljungman P., Jackson G., Kröger N., Rank A., Polge E., Rocha V., Mohty M. // Blood. 2012. V. 119. № 6. P. 1599. http://doi/org/10.1182/blood-2011-08-375840
  3. Christopeit M., Kuss O., Finke J. et al. // J. Clin. Oncol. 2010. V. 31. № 26. P. 3259. http://doi/org/10.1200/JCO.2012.44.7961
  4. Kröger N., Bornhäuser M., Stelljes M., Pichlmeier U., Trenschel R., Schmid C., Arnold R., Martin H., Heinzelmann M., Wolschke C., Meyer R. G., Bethge W., Kobbe G., Ayuk F., Gökbuget N., Hölzer D., Zander A., Beelen D. // Bone Marrow Transplant. 2014. V. 50. № 12. P. 1503. http://doi/org/10.1038/bmt.2015.202
  5. Каприн А.Д., Старинский А.В., Шахзадовой А.О. Состояние онкологической помощи населению России в 2022 году. М.: МНИОИ им. П.А. Герцена, 2022. 239 с.
  6. Мирзаахмедова И.З. // Экономика и социум. 2022. Т. 3. № 2. С. 94.
  7. Мамедова А.А., Мочкин Н.Е., Саржевский В.О. и др. // Онкогематология. 2022. Т. 17. № 3. С. 40. http://doi/org/10.17650/1818-8346-2022-17-3-40-47
  8. Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. // Гематология и трансфузиология. 2018. Т. 63. № 1-S2. С. 5.
  9. Azin F., Raie R.M., Mahmoudi M.M. // Ecotoxicology and Environmental Safety. 1998. V. 39. № 3. P. 179.
  10. Guidotti T.L., McNamara J., Moses M.S. // Indian J. Med. Res. 2008. V. 128. № 4. P. 524.
  11. Cui Y., Vogt S., Olson N., Glass A.G., Rohan T.E. // Cancer Epidemiol. Biomarkers Prevention. 2007. V. 16. № 8. P. 1682.
  12. Yelinova V., Glazachev Y., Khramtsov V., Kudryashova L., Rykova V., Salganik R. // Biochem. Biophys. Res. Commun. 1996. V. 221. № 2. P. 300.
  13. Ohanian M., Telouk P., Kornblau S., Albarede F., Ruvolo Peter, Tidwell R.S., Plesa A., Kangal-Shamanna R., Matera E., Cortes J., Carson A., Dumontet Ch. // Am. J. Hematology. 2020. V. 95. № 4. P. 422. http://doi/org/10.1002/ajh.25731
  14. Kul A. N., Ozturk Kurt B. // Clinical and Experimental Medicine. 2024. V. 24. № 1. P. 1. http://doi/org/10.1007/s10238-024-01349-5
  15. Qayyum M.A., Shah M.H. // Biol. Trace Elem. Res. 2020. V. 194. № 1. P. 34. http://doi/org/10.1007/s12011-019-01746-y
  16. Hasegawa T., InagakI K., Haraguchi H. // Analyt. Sci. 2001. V. 17. P. 979.
  17. Cirovic A., Cirovic A. // Leukemia Res. 2022. V. 112. Р. 106755. http://doi/org/10.1016/j.leukres.2021.106755
  18. Ehudin M.A., Golla U., Trivedi D., Potlakayala S.D., Rudrabhatla S.V., Desai D., Dovat S., Claxton D., Sharma A. // Int. J. Mol. Sci. 2022. V. 23. Р. 7972. http://doi/org/10.3390/ijms23147972
  19. Chrysochou E., Koukoulakis K., Kanellopoulos P.G., Sakellari A., Karavoltsos S., Dassenakis M., Minaidis M., Maropoulos G., Bakeas E. // J. Trace Elements Medicine Biol. 2021. V. 68. Р. 126833. http://doi/org/10.1016/j.jtemb.2021.126833
  20. Schmitt Y., Schneider H. // Nephrology Dialysis Transplantation. 1993. V. 8. № 5. P. 438.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2025 Russian Academy of Sciences

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).