GENERATION AND CHARACTERIZATION OF RECOMBINANT ANTIBODY AGAINST THE COMPLEMENT C5a ANAPHYLATOXIN

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Monoclonal mouse antibodies were raised against the human C5a anaphylatoxin. In these antibodies, the light- and heavy-chain constant regions were replaced by human IgG constant regions to produce chimeric mouse–human antibodies.

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A. Vasilishina

State Research Institute of Highly Pure Biopreparations

编辑信件的主要联系方式.
Email: a.a.vasilishna@hpb.spb.ru

MD, Biologist of Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

A. Demyanov

State Research Institute of Highly Pure Biopreparations

MD, Head of Laboratory of Immunopharmacology,

Saint Petersburg

俄罗斯联邦

V. Monahova

State Research Institute of Highly Pure Biopreparations

Biologist, Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

A. Zhakhov

State Research Institute of Highly Pure Biopreparations

Leading Researcher, Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

A. Trofimov

State Research Institute of Highly Pure Biopreparations

Group Leader, Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

E. Denisenko

State Research Institute of Highly Pure Biopreparations

Project Manager,

Saint Petersburg

俄罗斯联邦

K. Nekrasova

State Research Institute of Highly Pure Biopreparations

Deputy Head of R&D Department,

Saint Petersburg

俄罗斯联邦

S. Rodin

State Research Institute of Highly Pure Biopreparations

Group Leader, Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

A. Simbirtsev

State Research Institute of Highly Pure Biopreparations

RAS Corresponding Member, DMedSci, Professor, Scientific Supervisоr,

Saint Petersburg

俄罗斯联邦

A. Ischenko

State Research Institute of Highly Pure Biopreparations

PhD, Head of Laboratory of Protein Biochemistry,

Saint Petersburg

俄罗斯联邦

参考

  1. Chunguang Yan, Hongwei Gao. New insights for C5a and C5a receptors in sepsis. Front Immunol. 2012, 5, 197.
  2. Aird W. C. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003, 101, 3765–3777.
  3. Peter A. Ward Role of C5 Activation Products in Sepsis. The Scientific World Journal. 2010, 10, 2395– 24022010.

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版权所有 © Vasilishina A.A., Demyanov A.V., Monahova V.S., Zhakhov A.V., Trofimov A.V., Denisenko E.S., Nekrasova K.A., Rodin S.V., Simbirtsev A.S., Ischenko A.M., 2019

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