THE POSSIBLE ROLE OF MAST CELLS IN THE PATHOGENESIS OF SEVERE EXPERIMENTAL INFECTION IN MICE VACCINATED AGAINST INFLUENZA
- Authors: Mamontov A.S.1, Desheva Y.A.1, Nazarov P.G.1,2, Rudenko L.G.1
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Affiliations:
- Institute of Experimental Medicine
- The I. P Pavlov First Saint-Petersburg State Medical University
- Issue: Vol 20, No 3 (2017)
- Pages: 422-424
- Section: Articles
- URL: https://medbiosci.ru/1028-7221/article/view/119630
- ID: 119630
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Abstract
CBA mice were immunized parenterally with the NIBRG-14 vaccine strain of A/H5N1 influenza virus, and after 2 weeks they were infected with a high dose of the live IDCDC-RG2 strain of the A/H5N1 influenza virus. The course of the infection was severe and accompanied by high mortality. The injection of antihistamines (a mixtures of H1 and H2 histamine receptors blockers), at the time of infection, resulted in a 10% reduction in mortality (p<0.05). Data indicate that the severe course of influenza infection in vaccinated animals at least partially depends on the mast cells and histamine they release presumably upon activation by IgG antibodies and the virus.
About the authors
A. S. Mamontov
Institute of Experimental Medicine
Author for correspondence.
Russian Federation
Yu. A. Desheva
Institute of Experimental MedicineRussian Federation
P. G. Nazarov
Institute of Experimental Medicine; The I. P Pavlov First Saint-Petersburg State Medical UniversityRussian Federation
L. G. Rudenko
Institute of Experimental MedicineRussian Federation
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