ANTIMICROBIAL PEPTIDES IN THE TREATMENT OF MUSCULAR ORAL CAVITY
- Authors: Sarkisyan N.G.1, Kataev N.N.1, Tuzankina I.A.2, Melikyan S.G.1
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Affiliations:
- Ural state medical university of the ministry of health of the Russian Federation
- Institute of Immunology and Physiology Ural detachment of the Russian Academy of Sciences
- Issue: Vol 22, No 2-1 (2019)
- Pages: 524-526
- Section: ORIGINAL ARTICLES
- URL: https://medbiosci.ru/1028-7221/article/view/120290
- DOI: https://doi.org/10.31857/S102872210006952-2
- ID: 120290
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Abstract
Antimicrobial peptides are the most promising drugs in the replacement of antibiotic therapy. The results of the analysis of the physicochemical properties of Atsegram spray, in particular, surface tension (σ, Erg / cm2) and conductivity (æ, μS / cm) show the relationship with the mechanism of the antibacterial action of the drug and its eff ectiveness in the treatment of periodontitis. Spray application revealed an improvement in the hygienic condition of the oral cavity by a factor of 1.4, a decrease in the PMA index by 1.8 times, a decrease in the bleeding index of the gingival margin by a factor of 2 a month after treatment compared with the same indicators of the comparison group undergoing standard treatment.
About the authors
N. G. Sarkisyan
Ural state medical university of the ministry of health of the Russian Federation
Author for correspondence.
Email: narine_25@mail.ru
candidate of medical sciences, assistant, department of therapeutic dentistry and propedeutics of dental diseases,
Ekaterinburg
Russian FederationN. N. Kataev
Ural state medical university of the ministry of health of the Russian Federation
candidate of chemical sciences, assistant professor department of general chemistry,
Ekaterinburg
Russian FederationI. A. Tuzankina
Institute of Immunology and Physiology Ural detachment of the Russian Academy of Sciences
doctor of medicine, professor,
Ekaterinburg
Russian FederationS. G. Melikyan
Ural state medical university of the ministry of health of the Russian Federation
student,
Ekaterinburg
Russian FederationReferences
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