EVALUATION OF SINGLE NUCLEOTIDE POLYMORPHISMS -819C/T, -592C/A IL-10 IN PATIENTS WITH RHEUMATOID ARTHRITIS AS A GENETIC RISK FACTOR
- Authors: Stashkevich D.S.1, Suslova T.A.1,2, Burmistrova A.L.1
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Affiliations:
- Chelyabinsk State University
- Chelyabinsk Regional Blood Transfusion Station
- Issue: Vol 22, No 2-1 (2019)
- Pages: 572-574
- Section: ORIGINAL ARTICLES
- URL: https://medbiosci.ru/1028-7221/article/view/120305
- DOI: https://doi.org/10.31857/S102872210006978-0
- ID: 120305
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Abstract
The frequency distribution of the occurrence of alleles, genotypes and combinations of genotypes formed by SNPs -819, -592 IL-10 was assessed in this research. It was established that in the group of patients with RA, the distribution corresponds to that in European populations. No association of genetic polymorphism of SNPs -819, -592 IL-10 with a predisposition to RA in the Russians of the Chelyabinsk region was found.
About the authors
D. S. Stashkevich
Chelyabinsk State University
Author for correspondence.
Email: stashkevich_dary@mail.ru
cand. biol. Sci., Associate Professor, Department of Microbiology, Immunology and General Biology, Biological Faculty,
Chelyabinsk
Russian FederationT. A. Suslova
Chelyabinsk State University;Chelyabinsk Regional Blood Transfusion Station
cand. med. Sci., Associate Professor of the Department of Microbiology, Immunology and General Biology, Biological Faculty;
head. OMBD,
Chelyabinsk
Russian FederationA. L. Burmistrova
Chelyabinsk State University
dr. med. Sci., Head of the Department of Microbiology, Immunology and General Biology, Faculty of Biology,
Chelyabinsk
Russian FederationReferences
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