DYNAMICS OF CYTOKINE LEVELS IN BLOOD SERUM IN PATIENTS WITH METABOLIC SYNDROME USING STATINS
- 作者: Radaeva O.A.1, Simbirtsev A.S.2, Kostina Y.A.1, Iskandyarova M.S.1
-
隶属关系:
- National Research Mordovia State University
- State Research Institute of Highly Pure Biopreparations, FMBA
- 期: 卷 22, 编号 4 (2019)
- 页面: 1528-1530
- 栏目: ORIGINAL ARTICLES
- URL: https://medbiosci.ru/1028-7221/article/view/119682
- DOI: https://doi.org/10.31857/S102872210007079-1
- ID: 119682
如何引用文章
全文:
详细
The purpose of this research is to study the dynamics of the content in serum of IL-1β, IL-1α, IL-1ra, IL-18, IL-18BP, IL-37, IL-6, sIL-6r, LIF, sLIFr, IGF-1, TNF-α, sTNF -RI, IL-17, IL-2, IL-4, IL-10, TGF-β1, IL-8, CX3CL1, CXCL10, INFγ, M-CSF, IL-34, VEGF-A, EPO in patients with metabolic syndrome (MS) using statins. The use of statins for 6 months in patients with MS is characterized by a decrease in M-CSF to 399 [375–440] pg / ml (p <0.001) with a secondary increase in the concentration of the protective factor – sertuina-1 (p<0.001) and HDL, that blocks progression of atherosclerotic processes. The concentration of M-CSF in the range [395–454] pg / ml cancels its stimulating effect to synthesis of VEGF-A and slows the growth of coronary collaterals that maintaining a high risk of myocardial infarction (this effect is leveled when using statins for more than 6 months). The data obtained confirm the relevance of further research in this direction.
作者简介
O. Radaeva
National Research Mordovia State University
编辑信件的主要联系方式.
Email: radaevamed@mail.ru
PhD, docent of chair of Immunology, Microbiology, Virology,
Saransk
俄罗斯联邦A. Simbirtsev
State Research Institute of Highly Pure Biopreparations, FMBA
RAS Corresponding Member, DMedSci, Professor, Scientific Supervisоr,
St. Petersburg
俄罗斯联邦Yu. Kostina
National Research Mordovia State University
PhD, docent of chair of Immunology, Microbiology, Virology,
Saransk
俄罗斯联邦M. Iskandyarova
National Research Mordovia State University
assistant of chair of Immunology, Microbiology, Virology,
Saransk
俄罗斯联邦参考
- Oesterle A., Laufs U., Liao J. K. Pleiotropic Effects of Statins on the Cardiovascular System. Circ Res; 2017; 120(1), 229–243.
- Zeiser R. Immune modulatory effects of statins. Immunology. 2018;154(1), 69–75.
- Радаева О. А., Симбирцев А. С. М-CSF, IL-34, VEGF-A как факторы риска развития инфаркта миокарда, острого нарушения мозгового кровообращения у больных эссенциальной артериальной гипертензией. Российский иммунологический журнал. 2015; 9(18). № 1, 93–101.
- Okazaki T., Ebihara S., Asada M., Yamanda S., Saij o Y., Shiraishi Y., Ebihara T., Niu K., Mei H., Arai H., Yambe T. Macrophage colony-stimulating factor improves cardiac function after ischemic injury by inducing vascular endothelial growth factor production and survival of cardiomyocytes. Am. J. Pathol. 2007; 171, 1093–1103.
补充文件
