DYNAMICS OF CYTOKINE LEVELS IN BLOOD SERUM IN PATIENTS WITH METABOLIC SYNDROME USING STATINS
- Authors: Radaeva O.A.1, Simbirtsev A.S.2, Kostina Y.A.1, Iskandyarova M.S.1
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Affiliations:
- National Research Mordovia State University
- State Research Institute of Highly Pure Biopreparations, FMBA
- Issue: Vol 22, No 4 (2019)
- Pages: 1528-1530
- Section: ORIGINAL ARTICLES
- URL: https://medbiosci.ru/1028-7221/article/view/119682
- DOI: https://doi.org/10.31857/S102872210007079-1
- ID: 119682
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Abstract
The purpose of this research is to study the dynamics of the content in serum of IL-1β, IL-1α, IL-1ra, IL-18, IL-18BP, IL-37, IL-6, sIL-6r, LIF, sLIFr, IGF-1, TNF-α, sTNF -RI, IL-17, IL-2, IL-4, IL-10, TGF-β1, IL-8, CX3CL1, CXCL10, INFγ, M-CSF, IL-34, VEGF-A, EPO in patients with metabolic syndrome (MS) using statins. The use of statins for 6 months in patients with MS is characterized by a decrease in M-CSF to 399 [375–440] pg / ml (p <0.001) with a secondary increase in the concentration of the protective factor – sertuina-1 (p<0.001) and HDL, that blocks progression of atherosclerotic processes. The concentration of M-CSF in the range [395–454] pg / ml cancels its stimulating effect to synthesis of VEGF-A and slows the growth of coronary collaterals that maintaining a high risk of myocardial infarction (this effect is leveled when using statins for more than 6 months). The data obtained confirm the relevance of further research in this direction.
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About the authors
O. A. Radaeva
National Research Mordovia State University
Author for correspondence.
Email: radaevamed@mail.ru
PhD, docent of chair of Immunology, Microbiology, Virology,
Saransk
Russian FederationA. S. Simbirtsev
State Research Institute of Highly Pure Biopreparations, FMBA
RAS Corresponding Member, DMedSci, Professor, Scientific Supervisоr,
St. Petersburg
Russian FederationYu. A. Kostina
National Research Mordovia State University
PhD, docent of chair of Immunology, Microbiology, Virology,
Saransk
Russian FederationM. S. Iskandyarova
National Research Mordovia State University
assistant of chair of Immunology, Microbiology, Virology,
Saransk
Russian FederationReferences
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