Physical therapy in comprehensive treatment of peripheral artery disease and diabetes mellitus
- Authors: Kasymova A.R.1, Zamaletdinov T.R.1, Bikmetova A.E.2, Sultanova E.R.2, Bilalova L.I.2, Sedakova E.E.2, Shaikhutdinova K.M.2, Abdulmedzhidova Z.K.3, Antipina A.S.3, Bidzhieva A.A.4, Tupikov D.V.4, Dolaev R.R.4, Dzhatdoev R.R.4, Edieva R.R.4, Fedosova N.A.5
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Affiliations:
- Kazan State Medical University
- Bashkir State Medical University
- Astrakhan State Medical University
- Rostov State Medical University
- Orenburg State Medical University
- Issue: Vol 24, No 6 (2025)
- Pages: 407-421
- Section: Review
- URL: https://medbiosci.ru/1681-3456/article/view/364040
- DOI: https://doi.org/10.17816/rjpbr688677
- EDN: https://elibrary.ru/RZNBCU
- ID: 364040
Cite item
Abstract
Peripheral artery disease (PAD) and diabetes mellitus (DM) are serious medical and social issues that pose a significant risk of cardiovascular complications, amputations, and disability. The coexistence of these conditions worsens both survival and limb preservation, increases the severity of lower limb ischemia, and promotes trophic tissue disorders of the foot, including diabetic foot. The modern management of patients with PAD and DM relies on a multidisciplinary strategy, with physical therapists playing a key role. Their expertise encompasses improving physical activity, preventing complications, managing chronic wounds, and providing rehabilitation after vascular reconstructive surgery. This review summarizes current physical therapy approaches, including supervised exercise therapy (SET) for intermittent claudication, preoperative conditioning, early mobilization protocols, and restoration of motor activity following amputation or ulcer healing. Special emphasis is placed on offloading strategies for affected foot regions, physiotherapeutic techniques (laser therapy, magnetotherapy), and personalized exercise therapy programs for patients with DM. Furthermore, the review discusses barriers to SET implementation, including limited accessibility of programs, shortage of trained specialists, and patient referral challenges, as well as the need for educational and certification programs in chronic wound care for physical therapy and rehabilitation professionals. Clinical evidence suggests that integrating physical therapy into comprehensive treatment of patients with PAD and DM can improve limb function, reduce complication rates, and enhance quality of life.
About the authors
Aliya R. Kasymova
Kazan State Medical University
Email: alia18032003@yandex.ru
ORCID iD: 0009-0004-5647-849X
Russian Federation, Kazan
Timerkhan R. Zamaletdinov
Kazan State Medical University
Email: timerhan200209@gmail.com
ORCID iD: 0009-0007-1112-5406
Russian Federation, Kazan
Adelina E. Bikmetova
Bashkir State Medical University
Author for correspondence.
Email: ktrnkzhvnkv@gmail.com
ORCID iD: 0009-0001-3147-0852
Russian Federation, Ufa
Elina R. Sultanova
Bashkir State Medical University
Email: elinasultanova2001@mail.ru
ORCID iD: 0009-0006-6695-9304
Russian Federation, Ufa
Liliya I. Bilalova
Bashkir State Medical University
Email: liliabilalova98@gmail.com
ORCID iD: 0009-0006-5071-4038
Russian Federation, Ufa
Ekaterina E. Sedakova
Bashkir State Medical University
Email: ekaterina.sedakovaa@mail.ru
ORCID iD: 0009-0001-5190-0047
Russian Federation, Ufa
Kiriena M. Shaikhutdinova
Bashkir State Medical University
Email: shaikhutdinovakira@gmail.com
ORCID iD: 0009-0001-3062-5023
Russian Federation, Ufa
Zaripat K. Abdulmedzhidova
Astrakhan State Medical University
Email: zabdulmedzhidova2003@mail.ru
ORCID iD: 0009-0008-7496-4001
Russian Federation, Astrakhan
Anna S. Antipina
Astrakhan State Medical University
Email: aniuta.antipina2018@yandex.ru
ORCID iD: 0009-0008-2448-7788
Russian Federation, Astrakhan
Aminat A. Bidzhieva
Rostov State Medical University
Email: aminabidzieva59@gmail.com
ORCID iD: 0009-0003-5465-9257
Russian Federation, Rostov-on-Don
Danila V. Tupikov
Rostov State Medical University
Email: tupikov-danila@mail.ru
ORCID iD: 0009-0009-8051-9147
Russian Federation, Rostov-on-Don
Rolan R. Dolaev
Rostov State Medical University
Email: rolan.dolaev@mail.ru
ORCID iD: 0009-0002-8598-1962
Russian Federation, Rostov-on-Don
Rashid R. Dzhatdoev
Rostov State Medical University
Email: dzhatdoev.rashid@mail.ru
ORCID iD: 0009-0007-0946-7837
Russian Federation, Rostov-on-Don
Rada R. Edieva
Rostov State Medical University
Email: rada.edieva@gmail.com
ORCID iD: 0009-0000-8959-915X
Russian Federation, Rostov-on-Don
Natalya A. Fedosova
Orenburg State Medical University
Email: nata.fed2003@yandex.ru
ORCID iD: 0009-0006-5792-1152
SPIN-code: 1645-4567
Russian Federation, Orenburg
References
- Katorkin SE, Krivoshchekov EP, Elshin EB, Kushnarchuk MY. Modern possibilities and prospects of conservative treatment of patients with peripheral arterial diseases. Ambulatornaya khirurgiya. 2022;19(2):50–60. doi: 10.21518/1995-1477-2022-19-2-50-60 EDN: BXRIUM
- Gamzatov TH, Svetlikov AV. The modern principles of management of intermittent claudication. Pirogov Russian Journal of Surgery. 2016;(12):77–87. doi: 10.17116/hirurgia20161277-87 EDN: XVOVQJ
- Dedov II, Shestakova MV, Vikulova OK, et al. Diabetes mellitus in the Russian Federation: dynamics of epidemiological indicators according to the Federal Register of Diabetes Mellitus for the period 2010–2022. Diabetes mellitus. 2023;26(2):104–123. doi: 10.14341/DM13035 EDN: DVDJWJ
- Galstyan GR, Vikulova OK, Isakov MA, et al. Trends in the epidemiology of diabetic foot and lower limb amputations in Russian Federation according to the Federal Diabetes Register (2013–2016). Diabetes mellitus. 2018;21(3):170–177. doi: 10.14341/DM9688 EDN: XYEBFJ
- Dedov II, Shestakova MV, Vikulova OK. Epidemiology of diabetes mellitus in Russian Federation: clinical and statistical report according to the federal diabetes registry. Diabetes mellitus. 2017;20(1):13–41. doi: 10.14341/DM8664 EDN: YNEGHZ
- Armstrong DG, Boulton AJM, Bus SA. Diabetic Foot Ulcers and Their Recurrence. N Engl J Med. 2017;376(24):2367–2375. doi: 10.1056/NEJMra1615439
- Armstrong DG, Swerdlow MA, Armstrong AA, et al. Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res. 2020;13(1):16. doi: 10.1186/s13047-020-00383-2
- Barnes JA, Eid MA, Creager MA, Goodney PP. Epidemiology and Risk of Amputation in Patients With Diabetes Mellitus and Peripheral Artery Disease. Arterioscler Thromb Vasc Biol. 2020;40(8):1808–1817. doi: 10.1161/ATVBAHA.120.314595
- American Physical Therapy Association The economic value of physical therapy in the United States: a report from the American Physical Therapy Association. American Physical Therapy Association, Alexandria, VA; 2023.
- Moore KD, Hardin A, VanHoose L, Huang HH. Current Wound Care Education in Entry-Level Doctor of Physical Therapy Curricula. Adv Skin Wound Care. 2020;33(1):47–52. doi: 10.1097/01.ASW.0000613540.04323.38
- Moore KD, Sterling K, VanHoose L, et al. The prevalence of wound management physical therapist practice in the state of Texas. Physiother Theory Pract. 2023;39(2):414–422. doi: 10.1080/09593985.2021.2017092
- Kuchay AA, Lipin AN, Padaria ShF, et al. Chronic limb threatening ischemia — epidemiology, pathogenesis, diagnostics and treatment strategies. Russian Biomedical Research. 2024;9(3):53–61. doi: 10.56871/RBR.2024.95.99.007 EDN: BNJKML
- Stonko DP, Hicks CW. Current Management of Intermittent Claudication. Adv Surg. 2023;57(1):103–113. doi: 10.1016/j.yasu.2023.04.009
- Bezner JR. Promoting health and wellness: implications for physical therapist practice. Phys Ther. 2015;95(10):1433–1444. doi: 10.2522/ptj.20140271
- Souza DÚF, Monteiro DP, Pinto RZ, Pereira DAG. Supervised Exercise Therapy for Intermittent Claudication. Phys Ther. 2020;100(1):8–13. doi: 10.1093/ptj/pzz140
- Sandberg A, Bäck M, Cider Å, et al. Impact of walk advice alone or in combination with supervised or home-based structured exercise on patient-reported physical function and generic and disease-specific health related quality of life in patients with intermittent claudication, a secondary analysis in a randomized clinical trial. Health Qual Life Outcomes. 2023;21(1):114. doi: 10.1186/s12955-023-02198-8
- Harwood AE, Totty JP, Pymer S, et al. Cardiovascular and musculoskeletal response to supervised exercise in patients with intermittent claudication. J Vasc Surg. 2019;69(6):1899–1908.e1. doi: 10.1016/j.jvs.2018.10.065
- Jansen SC, Abaraogu UO, Lauret GJ, et al. Modes of exercise training for intermittent claudication. Cochrane Database Syst Rev. 2020;8(8):CD009638. doi: 10.1002/14651858.CD009638.pub3
- Zil-E-Ali A, Patel K, Goldfarb M, Aziz F. Postoperative decline in ambulatory function after lower extremity bypass is associated with higher short- and long-term mortality. J Vasc Surg. 2022;75(6):2002–2012.e3. doi: 10.1016/j.jvs.2022.01.122
- Otsuka S, Morisawa T, Yuguchi S, et al. Clinical importance of change in physical activity after endovascular treatment combined with exercise training in patients with peripheral arterial disease. Heart Vessels. 2017;32(2):143–148. doi: 10.1007/s00380-016-0856-4
- Matsuo T, Sakaguchi T, Ishida A, et al. Effect of in-hospital physical activity on cardiovascular prognosis in lower extremity bypass for claudication. J Phys Ther Sci. 2015;27(6):1855–9. doi: 10.1589/jpts.27.1855
- Matsuo T, Morimoto Y, Otsuka S, et al. Rehabilitation progress after lower-extremity bypass surgery in patients with peripheral arterial disease with different occlusive lesions. J Phys Ther Sci. 2021;33(3):261–266. doi: 10.1589/jpts.33.261
- Morisaki K, Guntani A, Kinoshita G, et al. Impact of ambulatory status change on survival in patients with chronic limb-threatening ischemia undergoing infrainguinal surgical or endovascular revascularization. J Vasc Surg. 2023;78(1):193–200.e2. doi: 10.1016/j.jvs.2023.03.024
- Frolov DV, Kryukov EV, Gerasimenko MY, Kulikov AG. Combined physical therapy for diabetic angiopathy. Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2020;19(1):25–31. doi: 10.17816/1681-3456-2020-19-1-4 EDN: PGPYPQ
- Mayorov AYu, Surkova EV, Motovilin OG, et al. Education of diabetic patients: synthesis of evidence-based medicine and psychological approach. Diabetes mellitus. 2011;14(1):46–52. doi: 10.14341/2072-0351-6249 EDN: OXKJYJ
- Volotovskaya AV, Kozlovskaya LE. Physical factors in the treatment of diabetes mellitus and its 33 complications scientific life. Russian Journal of Physiotherapy, Balneology and Rehabilitation. 2013;12(2):34–42. doi: 10.17816/41367 EDN: PYTBPP
- Tokmakova AY, Egorova DN, Doronina LP. Foot disorders in diabetes mellitus. Obesity and metabolism. 2017;14(1):41–47. doi: 10.14341/omet2017141-47 EDN: YRUSLT
- Kumar A, Hazari A, Maiya A, et al. Structured exercise program on Foot Biomechanics & Insulin Resistance among people living with type 2 diabetes with and without peripheral neuropathy. Diabetes mellitus. 2019;22(1):53–61. doi: 10.14341/DM9804
- Senneville É, Albalawi Z, van Asten SA, et al. IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023). Diabetes Metab Res Rev. 2024;40(3):e3687. doi: 10.1002/dmrr.3687
- Khramilin VN, Strokov IA, Davydov OS, Churyukanov MV. Diagnosis of diabetic polyneuropathy in primary care. Russian Journal of Pain. 2021;19(2):47–53. doi: 10.17116/pain20211902147 EDN: YVPKZG
- Batraeva AI, Burlyaeva VV, Mudrik IV, et al. The use of stem cells in the treatment of diabetic foot syndrome: analysis of clinical data (review). Endocrine Surgery. 2025;19(1):5–12. doi: 10.14341/serg12773 EDN: TVTSMQ
- Chiu A, Sharma D, Zhao F. Tissue Engineering-Based Strategies for Diabetic Foot Ulcer Management. Adv Wound Care (New Rochelle). 2023;12(3):145–167. doi: 10.1089/wound.2021.0081
- Islamova AI, Sabirova AR, Batyrshina ER, et al. New class of drugs for the treatment of diabetes mellitus. Clinical Medicine (Russian Journal). 2024;102(7):499–509. doi: 10.30629/0023-2149-2024-102-7-499-509 EDN: GYPTTF
- Belanger AY, Selkowitz DM, Lawson D. On Putting an End to the Backlash Against Electrophysical Agents. Int J Sports Phys Ther. 2023;18(5):1230–1237. doi: 10.26603/001c.87813
- Piercy KL, Troiano RP, Ballard RM, et al. The Physical Activity Guidelines for Americans. JAMA. 2018;320(19):2020–2028. doi: 10.1001/jama.2018.14854
- Kanaley JA, Colberg SR, Corcoran MH, et al. Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine. Med Sci Sports Exerc. 2022;54(2):353–368. doi: 10.1249/MSS.0000000000002800
- Demidova TYu, Titova VV. Advantages of physical activity of varying intensity for patients with type 1 diabetes and its influence on glucose metabolism. Obesity and metabolism. 2020;17(4):385–392. doi: 10.14341/omet12394 EDN: LYWMKF
- Thompson PD, Arena R, Riebe D, Pescatello LS; American College of Sports Medicine. ACSM's new preparticipation health screening recommendations from ACSM's guidelines for exercise testing and prescription, ninth edition. Curr Sports Med Rep. 2013;12(4):215–7. doi: 10.1249/JSR.0b013e31829a68cf
- Picha KJ, Howell DM. A model to increase rehabilitation adherence to home exercise programmes in patients with varying levels of self-efficacy. Musculoskeletal Care. 2018;16(1):233–237. doi: 10.1002/msc.1194
- Tran MM, Haley MN. Does exercise improve healing of diabetic foot ulcers? A systematic review. J Foot Ankle Res. 2021;14(1):19. doi: 10.1186/s13047-021-00456-w
- Wendland DM, Kline PW, Simmons L, Sinacore DR. The effect of exercise, physical activity, stepping characteristics, and loading on diabetic foot ulcer healing: a systematic review. Wounds. 2023;35(1):9–17. doi: 10.25270/wnds/22007
- Emery CF, Kiecolt-Glaser JK, Glaser R, Malarkey WB, Frid DJ. Exercise accelerates wound healing among healthy older adults: a preliminary investigation. J Gerontol A Biol Sci Med Sci. 2005;60(11):1432–6. doi: 10.1093/gerona/60.11.1432
- Smith D, Lane R, McGinnes R, et al. What is the effect of exercise on wound healing in patients with venous leg ulcers? A systematic review. Int Wound J. 2018;15(3):441–453. doi: 10.1111/iwj.12885
- Fernando ME, Woelfel SL, Perry D, et al. Dosing Activity and Return to Preulcer Function in Diabetes-Related Foot Ulcer Remission. J Am Podiatr Med Assoc. 2021;111(5). doi: 10.7547/20-166
- Mueller MJ. Mobility advice to help prevent re-ulceration in diabetes. Diabetes Metab Res Rev. 2020;36(1):e3259. doi: 10.1002/dmrr.3259
- Wendland DM, Altenburger EA, Swen SB, Haan JD. Diabetic Foot Ulcer Beyond Wound Closure: Clinical Practice Guideline. Phys Ther. 2025;105(1):pzae171. doi: 10.1093/ptj/pzae171
- Rodrigues M, Kosaric N, Bonham CA, Gurtner GC. Wound Healing: A Cellular Perspective. Physiol Rev. 2019 ;99(1):665–706. doi: 10.1152/physrev.00067.2017
- Waaijman R, de Haart M, Arts ML, et al. Risk factors for plantar foot ulcer recurrence in neuropathic diabetic patients. Diabetes Care. 2014;37(6):1697–705. doi: 10.2337/dc13-2470
- Armstrong DG, Holtz-Neiderer K, Wendel C, et al. Skin temperature monitoring reduces the risk for diabetic foot ulceration in high-risk patients. Am J Med. 2007;120(12):1042–6. doi: 10.1016/j.amjmed.2007.06.028
- Lavery LA, Higgins KR, Lanctot DR, et al. KA, Agrawal CM. Home monitoring of foot skin temperatures to prevent ulceration. Diabetes Care. 2004;27(11):2642–7. doi: 10.2337/diacare.27.11.2642
- Lavery LA, Higgins KR, Lanctot DR, et al. Armstrong DG, Agrawal CM. Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a self-assessment tool. Diabetes Care. 2007;30(1):14–20. doi: 10.2337/dc06-1600
- Najafi B, Grewal GS, Bharara M, et al. Can't Stand the Pressure: The Association Between Unprotected Standing, Walking, and Wound Healing in People With Diabetes. J Diabetes Sci Technol. 2017;11(4):657–667. doi: 10.1177/1932296816662959
- Gazzaruso C, Gallotti P, Pujia A, et al. Predictors of healing, ulcer recurrence and persistence, amputation and mortality in type 2 diabetic patients with diabetic foot: a 10-year retrospective cohort study. Endocrine. 2021;71(1):59–68. doi: 10.1007/s12020-020-02431-0
- Lin C, Liu J, Sun H. Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis. PLoS One. 2020;15(9):e0239236. doi: 10.1371/journal.pone.0239236
- Exterkate SH, Jongebloed-Westra M, Ten Klooster PM, et al. Objectively assessed long-term wearing patterns and predictors of wearing orthopaedic footwear in people with diabetes at moderate-to-high risk of foot ulceration: a 12 months observational study. J Foot Ankle Res. 2023;16(1):60. doi: 10.1186/s13047-023-00656-6
- Wada T, Matsumoto H, Hagino H. Customized exercise programs implemented by physical therapists improve exercise-related self-efficacy and promote behavioral changes in elderly individuals without regular exercise: a randomized controlled trial. BMC Public Health. 2019;19(1):917. doi: 10.1186/s12889-019-7270-7
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