Email this article Chronic hepatitis C: from long-term incidence changes to assessment of potential years of life lost (repeated cross-sectional studies)
- Authors: Sotskov A.Y.1, Isaeva N.V.1, Voronova E.A.1
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Affiliations:
- Academician Ye.A. Vagner Perm State Medical University
- Issue: Vol 24, No 3 (2025)
- Pages: 179-184
- Section: SOCIOLOGY OF HEALTH AND DISEASE
- URL: https://medbiosci.ru/1728-2810/article/view/363343
- DOI: https://doi.org/10.17816/socm683679
- EDN: https://elibrary.ru/XYNXUU
- ID: 363343
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Abstract
BACKGROUND: Chronic hepatitis C (CHC) remains one of the leading causes of viral hepatitis in Russia and worldwide, creating a significant social and economic burden, especially in working-age groups. Years of Potential Life Lost (YPLL), which is rarely used in Russian studies, is a sensitive social significance indicator of the disease.
AIM: This study aimed to assess the long-term changes of CHC incidence and population health losses in the Perm Territory using the YPLL as an indicator of the social, demographic, and economic burden of the disease.
METHODS: An epidemiological study was conducted based on published statistics and reporting on the incidence of viral hepatitis for 1999–2024 provided by Rospotrebnadzor in the Perm Territory. The study included all registered cases of acute and chronic viral hepatitis and deaths from CHC during the that period. A standard age of 70 years was used to calculate the YPLL. The calculations used the adopted formula: YPLL = ∑di × ai. The data are standardized per 100,000 population. Statistical processing was performed in the Statistica 8.0 suite and data visualization was performed in Microsoft Excel 2007.
RESULTS: In 1999–2024, the incidence of CHC had three epidemic phases, including growth, stabilization, and decline. In 2024, the actual incidence rate (24.3 per 100,000 population) exceeded the upper limit of the curvilinear trend confidence interval by 65.3%, indicating epidemic levels of CHC. The YPLL ranged from 46.5 to 219.2 years per 100,000 population, peaking in 2012 and showing another increase in 2020–2021 amid the COVID-19 pandemic. In 2024, the average YPLL was 47.3 years per 100,000 population.
CONCLUSION: In the Perm Territory, CHC epidemic has intensified since 2022. The YYPL confirmed the continuing social and demographic burden of CHC in the Perm Territory, showing the need to intensify screening and preventive efforts.
About the authors
Artem Yu. Sotskov
Academician Ye.A. Vagner Perm State Medical University
Author for correspondence.
Email: Sozkov1998a@mail.ru
ORCID iD: 0000-0003-0225-2925
SPIN-code: 7289-3843
Russian Federation, Perm
Natalia V. Isaeva
Academician Ye.A. Vagner Perm State Medical University
Email: nvisaeva@list.ru
ORCID iD: 0009-0007-0626-7979
SPIN-code: 3423-6491
MD, Dr. Sci. (Medicine), Professor
Russian Federation, PermElena A. Voronova
Academician Ye.A. Vagner Perm State Medical University
Email: ve-6971@mail.ru
ORCID iD: 0000-0003-4465-7453
SPIN-code: 3933-6759
MD, Сand. Sci. (Medicine), Assistant Professor
Russian Federation, PermReferences
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