Optimal duration of adjuvant trastuzumab therapy in patients with HER2-possitive early breast cancer: whether the problem is resolved?

Cover Page

Cite item

Full Text

Abstract

According to the results of the conducted studies in the early 2000’s, adjuvant trastuzumab for 1 year has been admitted the gold standard since 2006. However, the high cost of treatment and the increasing of the risk of cardiotoxicity have led to new clinical trials concerning the short-course trastuzumab regimen. The study deals with the results of the number of the largest randomized trials associated with the comparison of 6 months (the PHARE trial and the HORG study), 9 weeks (the Short-HER study and the SOLD study) and 12 months duration of adjuvant trastuzumab therapy in combination with chemotherapy in patients with HER2-possitive early breast cancer. Today, none of the studies has shown statistically significant evidence of the possibility to reduce the duration of adjuvant trastuzumab therapy.

About the authors

L G Zhukova

A.S.Loginov Moscow Clinical Scientific Practical Center of the Department of Health of Moscow

Email: zhukova.lyudmila@rambler.ru
д-р мед. наук, зам. дир. по онкологии 111123, Russian Federation, Moscow,sh. Entuziastov, d. 86

I P Ganshina

N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

канд. мед. наук, вед. науч. сотр. отд-ния химиотерапии и комбинированного лечения злокачественных опухолей 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

E I Khatkova

A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation

студентка 6-го курса лечебного фак-та 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1

T E Tikhomirova

People’s Friendship University of Russia

студентка 6-го курса Медицинского института, фак-т лечебное дело 117198, Russian Federation, Moscow, ul. Miklukho-Maklaya, d. 6

O E Kondratyeva

N.N.Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

клинический ординатор отд-ния химиотерапии и комбинированного лечения злокачественных опухолей 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

References

  1. Колядина И.В., Поддубная И.В. Современные возможности терапии HER2-положительного рака молочной железы (по материалам клинических исследований). Современная онкология. 2014; 16 (4): 10-20.
  2. Cameron D, Piccart-Gebhart M.J, Gelber et al. 11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial. The Lancet 2017; 389 (10075): 1195-205.
  3. Pivot X, Romieu G, Debled M et al. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): a randomised phase 3 trial. Lancet Oncol 2013; 14: 741-48.
  4. Kramar A, Bachelot T, Madrange N et al. Trastuzumab duration effects within patient prognostic subgroups in the PHARE trial. Ann Oncol 2014; 25: 1563-70.
  5. Franco Conte P et al. 9 weeks vs 1 year adjuvant trastuzumab in combination with chemotherapy: Results of the phase III multicentric Italian study Short-HER. ASCO 2017, abs 501.
  6. Mavroudis D et al. Six versus 12 months of adjuvant trastuzumab in combination with dose-dense chemotherapy for women with HER2-positive breast cancer: a multicenter randomized study by the Hellenic Oncology Research Group (HORG) Ann Oncol 2015; 26 (7): 1333-40.
  7. Joensuu H, Fraser J, Wildiers H et al. A randomized phase III study of adjuvant trastuzumab for a duration of 9 weeks versus 1 year, combined with adjuvant taxane-anthracycline chemotherapy, for early HER2-positive breast cancer (the SOLD study). SABCS abs. GS3-04.
  8. Kolyadina I, Ganshina I, Zhukova L et al. The first results of neoadjuvant therapy with the biosimilar of trastuzumab in HER2+ breast cancer stage II-III in routine Russian practice. Eur J Cancer 2018; 92 (S3): S107-108.
  9. Kolyadina I.V, Ganshina I, Zhukova L et al. The effectiveness, safety and economic rationality of the neoadjuvant chemotherapy with biosimilar of Trastuzumab in HER2+ breast cancer in Russian clinical practice. J Clin Oncol 2018; 36 (Suppl.; abstr e12656).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 


Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).