An innovative method of pregravid preparation of the “thin” endometrium during IVF
- Authors: Shneiderman M.G.1, Kalinina E.A.1, Smolnikova V.Y.1, Alieva K.U.1, Aksenenko A.A.1, Kuzemin A.A.1, Dyuzheva E.V.1, Gavisova A.A.1, Fatkhudinov T.K.1, Afyan A.I.1, Boris D.A.1, Apolikhina I.A.1
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Affiliations:
- V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
- Issue: Vol 32, No 9 (2025)
- Pages: 101-107
- Section: Obstetrics/gynecology
- URL: https://medbiosci.ru/2073-4034/article/view/368200
- DOI: https://doi.org/10.18565/pharmateca.2025.9.101-107
- ID: 368200
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Abstract
Background: In the context of declining fertility and in order to increase the effectiveness of the in vitro fertilization method when diagnosed with hypoplastic (thin) endometrium, the development of a new method of treating this pathology becomes relevant.
Objective: Development of a new effective method of treating hypoplastic (thin) endometrium without the use of standard treatment methods - hormone therapy and physiotherapy used in preparing patients for in vitro fertilization (IVF), and evaluation of the effectiveness and safety of the proposed innovative method.
Material and methods: The study included 260 patients of reproductive age (from 25 to 48 years) with diagnosed primary or secondary infertility and the presence of “thin endometrium” that was not treatable by other methods and did not respond to hormonal stimulation carried out in cycles three or four months before the start of the study. In the control group, 30 women with a clinically confirmed diagnosis of “infertility 1 or infertility 2, thin endometrium” were examined. The procedure for irrigation of the endometrium with carbon dioxide was carried out three times on the 7th, 9th and 11th days of the menstrual cycle. Statistical data processing was carried out using Statistica 10.0 software packages.
Results: After the patients underwent three irrigations of the endometrium with carbon dioxide, there was a clear trend towards an increase in the thickness of the endometrium. This indicates the potential of the method in increasing the number of successful embryo implantations during the IVF procedure.
Conclusion: Our own clinical observations accumulated confirm the high efficiency of using carbon dioxide (CO2) for irrigation of the uterine cavity with thin endometrium, which contributes to a significant increase in the endometrium thickness in the preparatory period before the IVF procedure.
About the authors
Mikhail G. Shneiderman
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: innamike@lmi.net
Cand.Sci. (Med.), Obstetrician-Gynecologist
Russian Federation, MoscowElena A. Kalinina
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: e_kalinina@oparina4.ru
Dr. Sci. (Med.), Head of the Department of Assisted Technologies in Infertility Treatment
Russian Federation, MoscowVeronika Yu. Smolnikova
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: dayana_boris@mail.ru
Dr. Sci. (Med.), Leading Researcher, Department of Assisted Technologies in Infertility Treatment
Russian Federation, MoscowKamila U. Alieva
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: kaya79@inbox.ru
Cand. Sci. (Med.), Researcher, Department of Assisted Technologies in Infertility Treatment
Russian Federation, MoscowArtem A. Aksenenko
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: a_axenenko@oparina4.ru
Cand. Sci. (Med.), Obstetrician-Gynecologist, 1st Gynecology Department
Russian Federation, MoscowAndrey A. Kuzemin
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: dayana_boris@mail.ru
Cand. Sci. (Med.), Head of the Day Hospital
Russian Federation, MoscowElena V. Dyuzheva
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: dug79@yandex.ru
Cand. Sci. (Med.), Obstetrician-Gynecologist, Department of Assisted Technologies in Infertility Treatment
Russian Federation, MoscowAlla A. Gavisova
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: gavialla@gmail.com
Dr. Sci. (Med.), Head of the 1st Gynecological Department
Russian Federation, MoscowTimur Kh. Fatkhudinov
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: tfat@yandex.ru
Dr. Sci. (Med.), Professor, Leading Researcher, Laboratory of Regenerative Medicine
Russian Federation, MoscowArmine I. Afyan
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: armineafyan@mail.ru
Obstetrician-Gynecologist
Russian Federation, MoscowDayana A. Boris
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Author for correspondence.
Email: dayana_boris@mail.ru
ORCID iD: 0000-0002-0387-4040
SPIN-code: 4832-0643
Cand. Sci. (Med.), Obstetrician-Gynecologist, Ultrasound Physician, Researcher at the Department of Aesthetic Gynecology and Rehabilitation
Russian Federation, MoscowInna A. Apolikhina
V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: apolikhina@inbox.ru
Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Aesthetic Gynecology and Rehabilitation
Russian Federation, MoscowReferences
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