Extrapelvic endometriosis: the mystery of the "black square" or "quintessential classics"?

Cover Page

Cite item

Full Text

Abstract

Endometriosis is still one of the most mysterious and urgent gynecological diseases. The prevalence of endometriosis is steadily increasing, despite the development of innovative methods of diagnosis and treatment. Endometriosis is the presence of a heterotopic endometrium outside the uterine cavity and most often affects the pelvic organs. However, more and more often, the world medical community actualizes the study of extrapelvic endometriosis as a unique clinical entity with specific pathogenetic patterns, approaches to verification, and therapeutic concepts. The article summarizes and systematizes the current scientific data on pathogenesis, clinical phenotypes, and therapy of extrapelvic endometriosis.

About the authors

Mekan R. Orazov

People’s Friendship University of Russia (RUDN University)

Author for correspondence.
Email: omekan@mail.ru
ORCID iD: 0000-0002-5342-8129

D. Sci. (Med.)

Russian Federation, Moscow

Viktor E. Radzinsky

People’s Friendship University of Russia (RUDN University)

Email: radzinsky@mail.ru
ORCID iD: 0000-0003-4956-0466

D. Sci. (Med.), Prof., Corr. Memb. RAS

Russian Federation, Moscow

Evgeny D. Dolgov

People’s Friendship University of Russia (RUDN University)

Email: 1586dolgde@gmail.com
ORCID iD: 0000-0001-6709-5209

Clinical Resident

Russian Federation, Moscow

Yuliya G. Abramashvili

Clinic “Estelife”

Email: gogiia@mail.ru
ORCID iD: 0000-0001-6322-1538

Obstetrician-Gynecologist

Russian Federation, Krasnodar

References

  1. Yilmaz BD, Bulun SE. Endometriosis and nuclear receptors. Hum Reprod Update. 2019;25(4):473-85.
  2. Hirata T, Koga K, Osuga Y. Extra-pelvic endometriosis: a review. Reprod Med Biol. 2020;19(4):323-33.
  3. Meggyesy M, Friese M, Gottschalk J, Kehler U. Case Report of Cerebellar Endometriosis. J Neurol Surg A Cent Eur Neurosurg. 2020;81(4):372-6.
  4. Tong SS, Yin XY, Hu SS, et al. Case report of pulmonary endometriosis and review of the literature. J Int Med Res. 2019;47(4):1766-70.
  5. McArthur GJ, Lowndes S, Meagher PJ. Endometriosis following free DIEP breast reconstruction. J Plast Reconstr Aesthet Surg. 2009;62(3):420-1.
  6. Anastasiu CV, Moga MA, Neculau EA, et al. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. Int J Mol Sci. 2020;21(5):1750. doi: 10.3390/ijms21051750
  7. Halme J, Hammond MG, Hulka JF, et al. Retrograde menstruation in healthy women and in patients with endometriosis. Obstet Gynecol. 1984;64(2):151-4.
  8. Yovich JL, Rowlands PK, Lingham S, et al. Pathogenesis of endometriosis: Look no further than John Sampson. Reprod Biomed Online. 2020;40(1):7-11.
  9. Dridi D, Chiaffarino F, Parazzini F, et al. Umbilical endometriosis: a systematic literature review and pathogenic theory proposal. J Clin Med. 2022;11(4):995.
  10. Bindra V, Reddy N, Reddy CA, et al. Recurrent perineal scar endometriosis: A case report. Case Rep Womens Health. 2022:e00457.
  11. Adamczyk M, Wender-Ozegowska E, Kedzia M. Epigenetic Factors in Eutopic Endometrium in Women with Endometriosis and Infertility. Int J Mol Sci. 2022;23(7):3804.
  12. Li Q, Xi M, Shen F, et al. Identification of Candidate Gene Signatures and Regulatory Networks in Endometriosis and its Related Infertility by Integrated Analysis. Reprod Sci. 2022;29(2):411-26.
  13. Yarahmadi G, Dehghanian M, Sandoghsaz RS, et al. Evaluation of NF1 and RASA1 gene expression in endometriosis. Eur J Obstet Gynecol Reprod Biol X. 2022;15:100152.
  14. Ren Y, Wang X, Guo J, et al. CHCHD2 Regulates Mitochondrial Function and Apoptosis of Ectopic Endometrial Stromal Cells in the Pathogenesis of Endometriosis. Reprod Sci. 2022:29(8):2152-64.
  15. Han SJ, Lee JE, Cho YJ, et al. Genomic Function of Estrogen Receptor β in Endometriosis. Endocrinology. 2019;160(11):2495-516.
  16. McKinnon B, Mueller M, Montgomery G. Progesterone Resistance in Endometriosis: An Acquired Property? Trends Endocrinol Metab. 2018;29(8):535-48.
  17. Fukui A, Mai C, Saeki S, et al. Pelvic endometriosis and natural killer cell immunity. Am J Reprod Immunol. 2021;85(4):e13342.
  18. Melioli G, Semino C, Semino A, et al. Recombinant interleukin-2 corrects in vitro the immunological defect of endometriosis. Am J Reprod Immunol. 1993;30(4):218-27. doi: 10.1111/j.1600-0897.1993.tb00623
  19. Smolarz B, Szyłło K, Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature). Int J Mol Sci. 2021;22(19):10554.
  20. Laganà AS, Garzon S, Götte M, et al. The pathogenesis of endometriosis: molecular and cell biology insights. Int J Mol Sci. 2019;20(22):5615.
  21. Aydin GA, Ayvaci H, Koc N, et al. The Relationship between Decorin and VEGF in Endometriosis. J Coll Physicians Surg Pak. 2021;31(11):1285-90. doi: 10.29271/jcpsp.2021.11.1285
  22. Grigore M, Socolov D, Pavaleanu I, et al. Abdominal wall endometriosis: an update in clinical, imagistic features, and management options. Med Ultrason. 2017;19(4):430-7.
  23. Cocco G, Delli Pizzi A, Scioscia M, et al. Ultrasound imaging of abdominal wall endometriosis: a pictorial review. Diagnostics. 2021;11(4):609.
  24. Sachdeva G, Divyashree PS, Shailaja N. A non-classical presentation of scar endometriosis during pregnancy: Case report and review of literature. JBRA Assist Reprod. 2022;26(3):563.
  25. Федеральные клинические рекомендации «Эндометриоз». М., 2020 [Federal'nyie klinicheskiie rekomendatsii “Endometrioz”. Moscow, 2020 (in Russian)].
  26. Оразов М.Р., Радзинский В.Е., Михалева Л.М., и др. Патогенез и патогенетическая терапия тазовой боли, обусловленной инфильтративным эндометриозом. Трудный пациент. 2021;19(2):35-41 [Orazov MB, Radzinsky VE, Mihaleva LM, et al. Pathogenesis and pathogenetic therapy of pelvic pain caused by infiltrating endometriosis. Difficult Patient. 2021;19(2):35-41 (in Russian)].
  27. Оразов М.Р., Радзинский В.Е., Орехов Р.Е., Таирова М.Б. Эффективность профилактики рецидивов после хирургического лечения эндометриоза яичников. Вопросы гинекологии, акушерства и перинатологии. 2022;21(3):53 [Orazov MR, Radzinsky VE, Orekhov RE, Tairova MB. Effectiveness of medical therapy for preventing ovarian endometriosis recurrence after surgical treatment. Voprosy ginekologii, akusherstva i perinatologii. 2022;21(3):53 (in Russian)].
  28. Оразов М.Р., Радзинский В.Е., Орехов Р.Е. Эффективность терапии эндометриоз-ассоциированной тазовой боли, резистентной к хирургическому лечению. Гинекология. 2021;23(4):314-23 [Orazov MR, Radzinsky VE, Orekhov RE. The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment. Gynecology. 2021;23(4):314-23 (in Russian)]. doi: 10.26442/20795696.2021.4.201097
  29. Maniglio P, Ricciardi E, Meli F, et al. Complete remission of cerebral endometriosis with dienogest: a case report. Gynecol Endocrinol. 2018;34(10):837-9.
  30. Ярмолинская М.И., Денисова В.М. Современные подходы к назначению add-back-терапии больным генитальным эндометриозом. Эффективная фармакотерапия. 2015;36:24-31 [Yarmolinskaya MI, Denisova VM. Modern Approaches to Add-Back Therapy in Patients with Genital Endometriosis. Effektivnaia farmakoterapiia. 2015;36:24-31 (in Russian)].

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2023 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).