The role of the anti-Müllerian hormone/anti-Müllerian hormone receptor type II signaling pathway in the eutopic and ectopic endometrium in patients with deep endometriosis: A cross-sectional study

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Abstract

Aim. To analyze the profile of anti-Müllerian hormone (AMH) and the expression level of the transmembrane AMH receptor type II (AMHRII) in the eutopic and ectopic endometrium of patients with deep infiltrative endometriosis (DIE).

Materials and methods. A comparative analysis of AMHRII expression in epithelial and stromal cells of eutopic and ectopic endometrial samples and the level of serum AMH in patients of reproductive age with DIE (n=50) and tuboperitoneal infertility (n=9) was performed.

Results. AMHRII expression in eutopic endometrial stromal cells of DIE patients was significantly higher compared to glandular cells in all study groups (p<0.5). AMHRII expression was found to be significantly higher in glandular cells of the eutopic endometrium compared to the ectopic endometrium of pelvic peritoneal foci in DIE patients: 1.60±0.77 and 1.09±0.68 points, respectively (p=0.001).

Conclusion. The inhibitory effect of AMH on cell proliferation and the proven expression of AMHRII by eutopic and ectopic endometrioid cells may indicate the role of AMH in the pathogenesis of endometriosis and endometriosis-associated infertility.

About the authors

Natalya A. Chekeneva

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: 4ekeneva@gmail.com
ORCID iD: 0009-0008-6645-6648

Obstetrician-Gynecologist, Sechenov First

Russian Federation, Moscow

Natalya A. Buralkina

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: natalyaburalkina@yandex.ru
ORCID iD: 0000-0001-5109-6725

D. Sci. (Med.)

Russian Federation, Moscow

Aleksandra V. Asaturova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: a.asaturova@gmail.com
ORCID iD: 0000-0001-8739-5209

D. Sci. (Med.), Obstetrics, Gynecology and Perinatology

Russian Federation, Moscow

Vladimir D. Chuprynin

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: v_chuprynin@oparina4.ru
ORCID iD: 0000-0002-2997-9019

Cand. Sci. (Med.), Gynecology and Perinatology

Russian Federation, Moscow

References

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2. Fig. 1. Anti-Müllerian hormone type II (AMHRII) expression in glandular and stromal eutopic endometrial cells in patients with deep infiltrative endometriosis – DIE (*p=0.0001, Mann–Whitney test).

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3. Fig. 2. AMHRII expression in stromal cells of the eutopic and ectopic endometrium in patients with DIE (*p=0.003, Mann–Whitney test).

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