Bemiparin sodium in prevention of tromboembolic complications in gynecological practices

The patients with complicated surgical diseases are relating to the group of high risk of nascence of vein thrombosis and tromboembolism. Aim of the study: to measure of the anticoagulant abilities of bemiparin sodium among women were operated by laparoscopic access in gynecological practices. Materials and methods. 15 women who had been operated for multiple uterine fibroid were examined and enrolled in the basic group. The patients were administered bemiparin sodium 3500 IE (0.2 ml) injected subcutaneously in 6 hours after operative treatment, then once a day during 7 days for prevention of tromboembolic complications in the postoperative period. The control group included 10 healthy women. The following parameters were defined for the control of efficiency of using of bemiparin sodium, his influence on different components of the haemostatic system: D-dimer, thrombocytes quantity and level of fibrinogen. Results. The significant elevation of level of D-dimer and fibrinogen was discovered among patients of the basic group during the preoperative period (p<0.05). The values of indicators of D-dimer and fibrinogen significantly decreased after therapy by bemiparin sodium. It was matched for the values in the control group. Conclusion. The using of bemiparin sodium in the postoperative period proved the high antitrombotic activity and the low risk of developing of bleeding.

thrombosis, tromboembolism, gynecological operations, low-molecular weight heparin, bemiparin sodium