Pathogenetic factors associated with formation of acute abdominal pain syndrome in dogs with gastroenteritis

Intercorrelative relationships between various clinical and laboratory parameters in dogs with acute gastroenteritis were studied. In dogs with acute alimentary gastroenteritis (n = 31), pain rating scale score significantly (p ≤ 0.05) correlated with pulse rate (r = 0.58), respiratory rate (r = 0.50), hematocrit (r = 0.47), ESR (r = 0.72), number of erythrocytes (r = 0.50) and leukocytes (r = 0.77), concentration of albumins (r = –0.52), globulins (r = 0.59), α1‑globulins (r = 0.49), α2‑globulins (r = 0.42), β-globulins (r = –0.36), γ-globulins (r = 0.59), C-reactive protein (r = 0.82), serum activity of ALT (r = 0.70), AST (r = 0.39), α-amylase (r = 0.38), alkaline phosphatase (r = 0.83) and serum concentration of creatinine (r = 0.42), tumor necrosis factor-α (r = 0.82), interleukin‑4 (r = 0.92), interleukin‑6 (r = 0.92), interferon-γ (r = 0.91), interleukin‑1α (r = 0.85), interleukin‑8 (r = 0.91). The following changes were noted in the body of dogs with acute gastroenteritis: local and systemic immune-­inflammatory response activated, pain, intoxication, dehydration syndrome, disorders of motor, secretory, absorption, excretory function of gastrointestinal tract formed, secondary hepatopathy and pancreatopathy developed. In dogs with acute gastroenteritis, there were also statistically significant (p ≤ 0.05) correlations between the number of erythrocytes and hematocrit (r = 0.65), MCHC (r = 0.32), ESR (r = 0.35), hemoglobin concentration (r = 0.73) and leukocyte count (r = 0.35); between MCV and hematocrit (r = 0.62), MCHC (r = –0.64); between MCV and MCHC (r = –0.64); MCH and MCHC (r = 0.40); ESR and leukocyte count (r = 0.53). Changes in intercorrelative relationships between clinical and laboratory parameters in dogs with acute gastroenteritis can be considered as predictors of severity of the pathological process.