Email this article Correction of iron deficiency in patients with abnormal uterine bleeding
- Authors: Ozolinya L.A.1, Savchenko T.N.1, Golovko E.D.1
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Affiliations:
- N.I. Pirogov Russian National Research Medical University
- Issue: Vol 9, No 3 (2022)
- Pages: 173-180
- Section: Original study articles
- URL: https://medbiosci.ru/2313-8726/article/view/111032
- DOI: https://doi.org/10.17816/2313-8726-2022-9-3-173-180
- ID: 111032
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Abstract
INTRODUCTION: Iron deficiency (ID) occurring latently or as iron deficiency anemia (IDA) is common in gynecology, particularly in patients with abnormal uterine bleeding (AUB).
AIM: We aimed at exploring the efficiency of a medication containing ferrous sulfate and multivitamins for the correction of latent ID and treatment of mild IDA in AUB patients.
MATERIALS AND METHODS: We performed a comprehensive clinical, laboratory, and instrumental examination of 60 women aged 35 to 50 years with AUB, revealing many gynecological pathologies (endometrial polyps or hyperplasia, ade nomyosis, and uterine myoma). The examined patients with AUB were divided into two groups: women with latent ID (group 1, n=38) and women with IDA (group 2, n=22). Moreover, all the patients had extragenital pathology in addition to gynecological diseases. As a treatment, ferrous sulfate with multivitamins was prescribed for 1–3 months.
RESULTS: Before treatment, the hemoglobin level in the examined patients ranged from 95 to 130 g/L, with an average of 127.1±1.8 g/L in group 1 and 100.3±2.1 g/L in group 2. Serum iron concentrations in the examined groups were 9.8±0.2 and 6.9±1.3 μmol/L, respectively. After treatment, the average levels of hemoglobin and serum iron increased significantly and reached normal levels in all those examined. Hemoglobin was 143.3±1.8 g/L in group 1 and 122.5±1.5 g/L in group 2, whereas serum iron was 14.9±0.2 μmol/L in group 1 and 13.5±1.0 μmol/L in group 2. Furthermore, a significant increase to normal values was observed in other indicators of complete blood count and biochemical analysis.
CONCLUSIONS: The results of the study reveal a high clinical efficiency of ferrous sulfate and multivitamins in the treatment of ID in patients with AUB.
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##article.viewOnOriginalSite##About the authors
Lyudmila A. Ozolinya
N.I. Pirogov Russian National Research Medical University
Author for correspondence.
Email: ozolinya@yandex.ru
ORCID iD: 0000-0002-2353-123X
SPIN-code: 9407-9014
MD, Dr. Sci. (Med.), Professor
Russian Federation, 1, Ostrovityanova str., Moscow, 117198Tat’yana N. Savchenko
N.I. Pirogov Russian National Research Medical University
Email: 12111944t@mail.ru
ORCID iD: 0000-0001-7244-4944
SPIN-code: 3157-3682
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowElizaveta D. Golovko
N.I. Pirogov Russian National Research Medical University
Email: e.d.golovko@mail.ru
ORCID iD: 0000-0001-6648-3103
SPIN-code: 3453-6078
student
Russian Federation, MoscowReferences
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