NATURE OF METABOLIC AND FUNCTIONAL CONDITION OF CELLULAR FACTORS OF CONGENITAL IMMUNITY IN RHINOSURGICAL PATIENTS IN EARLY POST-OPERATIVE PERIOD

Aim - to study the peculiarities of metabolic and functional activity of cell factors of congenital immunity in patients after rhinosurgical treatment in early stages of post-operative period. Materials and methods. The authors examined leukocyte profile of nasal secretion and their viability, phagocytic and lysosomal activity, oxygen-dependent biotransformation of neutrophilic granulocytes in NBT-test during the first 24 hours after the operation for deflection of the nasal septum. Results. The study showed that spontaneous NBT-test during the first 24 hours of postoperative period revealed that patients after the operation for deflection of the nasal septum with the following 24-hour tamponade have increased number of viable neutrophilic granulocytes with better lysosomal activity, decreased phagocytosis activity and intensity, and depressed biocidal characteristics. Conclusion. The revealed increase in the number of viable neutrophilic granulocytes, their better lysosomal activity, associated with decreased phagocytosis activity and intensity, and depressed biocidal characteristics prove the need for the search of additional methods of postoperative rehabilitation.

nasal septum, nasal secretion, congenital immunity, neutrophilic granulocytes