Coagulation profile depending on ABО blood group system

Cover Page

Cite item

Full Text

Abstract

Objectives – to compare the parameters of hemostasis in representatives of various blood groups using the ABО system.

Material and methods. The study involved 51 people (mean age 19.8±0.5 year). The parameters of the coagulation, anticoagulation and fibrinolytic systems were determined for all the examined persons. The following hemostasis parameters were investigated: coagulation factors (II, VII, VIII, IX, X, XI, XII), APTT, prothrombin time, plasminogen, antiplasmin, antithrombin III, protein C.

Results. The obtained results indicate the presence of biological variation of blood coagulation parameters depending on the antigenic affiliation of the blood group according to the ABО system, which is manifested in a change in the concentration and activity of a number of coagulation factors. The revealed tendencies made it possible to form a coagulation profile depending on the group of blood in the ABО system.

Conclusion. The study of variability of coagulation parameters, depending on the group of blood in the ABО system, is an important step towards the formation of personalized approach in laboratory research.

About the authors

Oksana A. Gusyakova

Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-5619-4583

PhD, Associate Professor, Head of the Chair of fundamental and clinical biochemistry with laboratory diagnostics, Head of the Clinical and Diagnostic Laboratory

Russian Federation, Samara

Frida N. Gilmiyarova

Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0001-5992-3609

Honored PhD, Professor, Chair of fundamental and clinical biochemistry with laboratory diagnostics

Russian Federation, Samara

Alyona A. Ereshchenko

Samara State Medical University

Author for correspondence.
Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-4221-4440

assistant of the Chair of fundamental and clinical biochemistry with laboratory diagnostics

Russian Federation, Samara

Valeriya I. Kuzmicheva

Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-5232-1549

resident of the Chair of fundamental and clinical biochemistry with laboratory diagnostics

Russian Federation, Samara

Inessa A. Borodina

Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0001-7115-6430

resident of the Chair of fundamental and clinical biochemistry with laboratory diagnostics

Russian Federation, Samara

Elena E. Potyakina

Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-1382-1831

assistant of the Chair of fundamental and clinical biochemistry with laboratory diagnostics

Russian Federation, Samara, Russia

References

  1. Daniels G, Reid ME. Blood groups: the past 50 years. Transfusion. 2010;50(2):281-9. doi: 10.1111/j.1537-2995.2009.02456.x
  2. Xu X, Xu F, Ying Y, Hong X, Liu Y, Chen S, He J, Zhu F, Hu W. ABО antigen levels on platelets of normal and variant ABО blood group individuals. Platelets. 2018;1–7. doi: 10.1080/09537104.2018.1543863
  3. Eastlund T. The histo-blood group ABО system and tissue transplantation. Transfusion. 1998;38:975–88. doi: 10.1046/j.1537-2995.1998.381098440863
  4. Franchini M, Liumbruno GM. ABО blood group: old dogma, new perspectives. Clinical Chemistry and Laboratory Medicine. 2013;51(8):1545–53. doi: 10.1515/cclm-2013-0168
  5. Dong R, Wang N, Yang Y, et al. Review on Vitamin K Deficiency and its Biomarkers: Focus on the Novel Application of PIVKA-II in Clinical Practice. Clinical Laboratory. 2018;64(4):413–424. doi: 10.7754/Clin.Lab.2017.171020
  6. Koster T, Blann AD, Briet E, Vandenbroucke JP, Rosendaal FR. Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis. Lancet. 1995;345:152–155.
  7. Kosiakova YuA, Davidkin IL, Stepanova TYu, Kurtov IV, Kudinova NA. [Evaluation of anemia syndrom in haemophilia]. Vestnik Rossijskogo universiteta druzhby narodov. Serija: Medicina. 2010;4:258–259. (In Russ.). Косякова Ю.А., Давыдкин И.Л., Степанова Т.Ю., Куртов И.В., Кудинова Н.А. Оценка синдрома анемии при гемофилии. Вестник Российского университета дружбы народов. Серия: Медицина. 2010;4:258–259.
  8. Kosiakova YuA. [Blood biochemistry parameters in patients with hemophilia]. Kazanskij medicinskij zhurnal. 2013;94(5):707–710. (In Russ.). Косякова Ю.А. Биохимические показатели крови у больных гемофилией. Казанский медицинский журнал. 2013;94(5):707–710.
  9. Berkovskij AL, Sergeeva EV, Suvorov AV, Kozlov AA. [External path of blood clotting. Methods of research. Methodological guidance]. Moscow: RENAM, 2017. (In Russ.). Берковский А.Л., Сергеева Е.В., Суворов А.В., Козлов А.А. Внешний путь свертывания крови. Методы исследования. Методическое руководство. М.: РЕНАМ, 2017.
  10. Smith NL, Chen MH, Dehghan A, et al. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010;121(12):1382–92. doi: 10.1161/CIRCULATIONAHA.109.869156
  11. Canis K, McKinnon TA, Nowak A, et al. The plasma von Willebrand factor O-glycome comprises a surprising variety of structures including ABH antigens and disialosyl motifs. Journal of thrombosis and haemostasis. 2010;8(1):137–45. doi: 10.1111/j.1538-7836.2009.03665.x
  12. Petrova OV, Urtaeva ZA, Shashin SA, Tarasov DG. [Reference hemostasis intervals of values in the adult population of the Astrakhan region using automatic coagulometr "STA Compact"]. Medicinskij vestnik Juga Rossii. 2016;2:63–66. (In Russ.). Петрова О.В., Уртаева З.А., Шашин С.А., Тарасов Д.Г. Референтные интервалы показателей системы гемостаза у взрослого населения Астраханской области при применении автоматического коагулометра «STA Compact». Медицинский вестник Юга России. 2016;2:63–66.
  13. Kozlov AA, Berkovskij AL, Sergeeva EV, Suvorov AV. [Preanalytical phase in hemostasiology]. Moscow: Print, 2013. (In Russ.). Козлов А.А., Берковский А.Л., Сергеева Е.В., Суворов А.В. Преаналитический этап в гемостазиологии. М.: Принт, 2013.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Gusyakova O.A., Gilmiyarova F.N., Ereshchenko A.A., Kuzmicheva V.I., Borodina I.A., Potyakina E.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).