Modern opportunities for diagnostics of chronic endometritis

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Abstract

The indices of local immunity were studied by the immunohistochemical method in the endometrium from 151 women with morphological manifestations of chronic endometritis. To confirm the inflammatory process and clarify its nature, the parameters of systemic immunity were studied. According to changes in the parameters of local immunity, three groups of patients were identified. Determination of the parameters of systemic immunity made it possible to confirm chronic endometritis in all women and to identify a group with an autoimmune nature of inflammation.

About the authors

V. N. Ellinidi

All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg

N. I. Davydova

All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg

N. M. Kalinina

All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg

Е. А. Mikhnina

All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg

О. А. Dobrotvortseva

All-Russian Center for Emergency and Radiation Medicine, EMERCOM of Russia; Research Institute of Obstetrics and Gynecology named after D.O. Otta RAMS

Email: info@eco-vector.com
Russian Federation, Saint Petersburg; Saint Petersburg

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2. Fig. 1. Subpopulation composition of peripheral blood lymphocytes in women depending on the number of lymphocytes expressing CD56 + in the endometrium

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3. Fig. 2. The number of peripheral blood lymphocytes expressing activation markers (CD25 +, CD95 +, HLA (II) in women, depending on the number of lymphocytes in the endometrium expressing CD56 +

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4. Fig. 3. Production of growth factor IL-2 in women depending on the number of lymphocytes expressing CD56 + in the endometrium

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5. Fig. 4. The content of immunoglobulins in blood serum (IgA, IgM, IgG, slgA) and circulating immune complexes in the blood of women, depending on the number of lymphocytes in the endometrium expressing CD56 +

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6. Fig. 5. Changes in circulating immune complexes, the presence of inflammatory processes in all study groups. TNF-α and INF-γ affect the cytotoxic activity of natural killer cells of the endometrium, realizing it by Fas-dependent or perforin-mediated

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7. Fig. 6. Production of cytokines Th1 (TNF-a, INF-γ) and Th2 (IL-4) in women depending on the number of lymphocytes expressing CD56 + in the endometrium

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