One-carbon metabolism prognostic markers in the development of acute myocardial infarction in patients after COVID-19
- Авторлар: Evteeva D.A.1, Gaikovaya L.B.1, Vohmyanina N.V.1, Asatryan T.T.1, Shchetinina K.A.1
-
Мекемелер:
- Northwestern State Medical University named after I.I. Mechnikov
- Шығарылым: Том 28, № 12 (2025)
- Беттер: 69-76
- Бөлім: Medical chemistry
- URL: https://medbiosci.ru/1560-9596/article/view/362637
- DOI: https://doi.org/10.29296/25877313-2025-12-08
- ID: 362637
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Introduction. The SARS-CoV-2 virus affects the cardiovascular system, having long-term consequences, and leads to an increased risk of developing CVD diseases. To prevent the development of complications, it is important to search for predictors of cardiovascular pathology.
Purpose of the study – to evaluate the prognostic significance of homocysteine, folic acid, and genetic polymorphisms of folate cycle and endothelial synthase genes in the development of acute myocardial infarction (AMI) in patients after a new coronavirus infection.
Material and methods. A case-control study, the study group consisted of patients after COVID-19, confirmed by PCR, of moderate or severe form, for a period of 6 to 24 months, the main group with AMI, the control group without AMI. All patients underwent studies of serum homocysteine and folic acid levels and molecular genetic studies (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, MTRR 66 A>G, NOS3 -786 T>C, NOS3 894 G>T).
Results. In patients after COVID-19, a violation of one-carbon metabolism due to hyperhomocysteinemia was found, as well as a high risk of AMI in middle-aged patients with an increase in homocysteine levels in the blood of more than 14.3 mmol/l and carriage of the NOS3 -786 gene.
Conclusion. An imbalance of one-carbon metabolism markers and the presence of polymorphism of endothelial synthase genes contributes to the development of acute myocardial infarction after COVID-19 in middle-aged patients.
Негізгі сөздер
Авторлар туралы
D. Evteeva
Northwestern State Medical University named after I.I. Mechnikov
Хат алмасуға жауапты Автор.
Email: doc.evteeva@yandex.ru
ORCID iD: 0000-0001-5756-2088
SPIN-код: 3468-6619
Post-graduate Student, the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Ресей, 41 Kirochnaya str., Saint Petersburg, 191015L. Gaikovaya
Northwestern State Medical University named after I.I. Mechnikov
Email: larisa.gaikovaya@szgmu.ru
ORCID iD: 0000-0003-1000-1114
SPIN-код: 9424-1076
Dr.Sc. (Med.), Professor, Head of the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Ресей, 41 Kirochnaya str., Saint Petersburg, 191015N. Vohmyanina
Northwestern State Medical University named after I.I. Mechnikov
Email: spbnat@yandex.ru
ORCID iD: 0000-0002-7162-9362
SPIN-код: 7414-4257
Dr.Sc. (Med.), Professor of the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Ресей, 41 Kirochnaya str., Saint Petersburg, 191015T. Asatryan
Northwestern State Medical University named after I.I. Mechnikov
Email: Tatevik.Asatryan@szgmu.ru
ORCID iD: 0000-0002-9146-3080
SPIN-код: 5587-1360
Ph.D. (Med.), Associate Professor of the Department of Clinical Laboratory Diagnostics, Biological and General Chemistry named after V.V. Sokolovsky
Ресей, 41 Kirochnaya str., Saint Petersburg, 191015K. Shchetinina
Northwestern State Medical University named after I.I. Mechnikov
Email: karishasuper11@gmail.com
ORCID iD: 0009-0002-1675-7166
Student, Fundamental Medicine Institute
Ресей, 41 Kirochnaya str., Saint Petersburg, 191015Әдебиет тізімі
- Corrales-Medina V.F., Alvarez K.N., Weissfeld L.A. et al. Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease. JAMA. 2015; 313: 264. doi: 10.1001/jama.2014.18229.
- Ponti G., Pastorino L., Manfredini M. et al. COVID‐19 spreading across world correlates with C677T allele of the methylenetetrahydrofolate reductase (MTHFR) gene preva-lence. J Clin Lab Anal. 2021; 35. doi: 10.1002/jcla.23798.
- Kotecha T., Knight D.S., Razvi Y. et al. Patterns of myo-cardial injury in recovered troponin-positive COVID-19 pa-tients assessed by cardiovascular magnetic resonance. Eur Heart J. 2021; 42: 866–1878. doi: 10.1093/eur-heartj/ehab075.
- Mahmoodi K., Soltanpour M., Kamali K. Assessment of the role of plasma nitric oxide levels, T-786C genetic poly-morphism, and gene expression levels of endothelial nitric oxide synthase in the development of coronary artery disease. J Res Med Sci. 2017; 22: 34. doi: 10.4103/1735-1995.202144.
- Jukic I., Heffernan A., Schelling A.F. et al. Association between COVID-19 Infection or Vaccination Outcomes and Methylenetetrahydrofolate Reductase Gene Polymorphism: A Systematic Review of the Literature. J Pers Med. 2023; 13: 1687. doi: 10.3390/jpm13121687.
- Koklesova L., Mazurakova A., Samec M. et al. Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person. EPMA J. 2021; 12: 477–505. doi: 10.1007/s13167-021-00263-0.
- Refsum H., Smith A.D., Ueland P.M. et al. Facts and Reco-mmendations about Total Homocysteine Determina-tions: An Expert Opinion. Clin Chem. 2004; 50: 3–32. doi: 10.1373/clinchem.2003.021634.
- Salimi S., Naghavi A., Firoozrai M. et al. Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery di-sease. Pathophysiology. 2012; 19: 157–162. doi: 10.1016/j.pathophys.2012.04.003.
- Miñana G., Gil-Cayuela C., Fácila L. et al. Homocysteine and long-term recurrent infarction following an acute coro-nary syndrome. Cardiol J. 2021; 28: 598–606. doi: 10.5603/CJ.a2020.0170.
- Chen L., Liu L., Hong K. et al. Three Genetic Polymorphisms of Homocysteine-Metabolizing Enzymes and Risk of Coro-nary Heart Disease: A Meta-Analysis Based on 23 Case–Control Studies. DNA Cell Biol. 2012; 31: 238–249. doi: 10.1089/dna.2011.1281.
- Whayne T.F. Methylenetetrahydrofolate Reductase C677T Polymorphism, Venous Thrombosis, Cardiovascular Risk, and Other Effects. Angiology [Internet]. 2015; 66: 401–404. Available from: https://journals.sagepub.com/doi/10.1177/0003319714548871. doi: 10.1177/0003319714548871.
- Евтеева Д.А. Гайковая Л.Б. Показатели одноуглеродного метаболизма у кардиологических пациентов в разные ср-оки после перенесенной новой коронавирусной инфек-ции. Вопросы биологической, медицинской и фармацев тической химии. 2025; 28(2): 3−9. [Evteeva D.A., Gai-kovaya L.B. One-carbon metabolism markers in cardiac patients at different times after a new coronavirus infection. Probl Biol Med Pharm Chem. 2025; 24–31. (In Russ.)]. DOI: 0.29296/25877313-2025-02-00.
- Бойцов С.А., Шахнович Р.М., Терещенко С.Н. и др. Кли-нико-анамнестические и демографические особенности пациентов с инфарктом миокарда в Российской Федерации по данным Российского регистра острого инфаркта миокарда – РЕГИОН–ИМ. Кардиология. 2024; 64(4): 3–13. [Boytsov S.A., Shakhnovich R.M., Tereschenko S.N. et al. Clinical, Anamnestic, and Demographic Characteristics of Patients with Myocardial Infarction in Russian Federation According to the Russian Registry of Acute Myocardial Infarction – REGION– IM. Kardiologiia. 2024; 64(4): 3–13. (In Russ.)]. doi: 10.18087/cardio.2024.4.n2625.
- Fácila L., Nuñez J.E., Bertomeu G.V. et al. Early deter-mination of homocysteine levels in acute coronary synd-romes, is it an independent prognostic factor? Int J Cardiol. 2005; 100: 275–279. doi: 10.1016/j.ijcard.2004.09.001.
- Fan Y. Homocysteine enhances the predictive value of the GRACE risk score in patients with ST-elevation myocardial infarction. Anatol J Cardiol. 2017; 18(3): 182–193. DOI: 10.14744 /AnatolJCardiol.2017.7798.
- Martí-Carvajal A.J., Solà I., Lathyris D. et al. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017; 2021. doi: 10.1002/14651858.CD006612.pub5.
- Xie X., Shi X., Xun X. et al. Endothelial nitric oxide synthase gene single nucleotide polymorphisms and the risk of hy-pertension: A meta-analysis involving 63,258 subjects. Clin Exp Hypertens. 2017; 39: 175–182. doi: 10.1080/10641963.2016.1235177.
- Lapić I., Radić Antolic M., Horvat I. et al. Association of polymorphisms in genes encoding prothrombotic and car-diovascular risk factors with disease severity in COVID‐19 patients: A pilot study. J Med Virol. 2022; 94: 3669–3675. doi: 10.1002/jmv.27774.
- Бойко А.Н., Шамалов Н.А., Бойко О.В. и др. Первый опыт использования препарата ангиовит в комплексном лече-нии острой стадии инфекции COVID-19. Неврология, ней-ропсихиатрия, психосоматика. 2020; 12(3): 82–86. [Boyko A.N., Shamalov N.A., Boyko O.V. et al. The first experience with Angiovit in the combination treatment of acute COVID-19 infection. Neurol Neuropsychiatry, Psychosom. 2020; 12: 82–86. (In Russ.]. doi: 10.14412/2074-2711-2020-3-82-86
- Гайковая Л.Б., Евтеева Д.А., Вохмянина Н.В. Определение фолиевой кислоты в крови у пациентов с новой коро-навирусной инфекцией. Современные достижения химико-биологических наук в профилактической и клинической медицине. 2021: 227–231. [Gaikovaya L.B., Evteeva D.A., Vokhmyanina N.V. Determination of folic acid in blood in patients with new coronaviral infection. In: Gaikovaya L.B., Silin A.V., editors. Sovrem dostizheniya khimiko-bio-logicheskikh Nauk v Profil i Klin Med. Saint-Petersburg: North-Western Mechnikov State Medical University. 2021: 227–231. (In Russ.)].
Қосымша файлдар
