One-carbon metabolism prognostic markers in the development of acute myocardial infarction in patients after COVID-19
- Authors: Evteeva D.A.1, Gaikovaya L.B.1, Vohmyanina N.V.1, Asatryan T.T.1, Shchetinina K.A.1
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Affiliations:
- Northwestern State Medical University named after I.I. Mechnikov
- Issue: Vol 28, No 12 (2025)
- Pages: 69-76
- Section: Medical chemistry
- URL: https://medbiosci.ru/1560-9596/article/view/362637
- DOI: https://doi.org/10.29296/25877313-2025-12-08
- ID: 362637
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Abstract
Introduction. The SARS-CoV-2 virus affects the cardiovascular system, having long-term consequences, and leads to an increased risk of developing CVD diseases. To prevent the development of complications, it is important to search for predictors of cardiovascular pathology.
Purpose of the study – to evaluate the prognostic significance of homocysteine, folic acid, and genetic polymorphisms of folate cycle and endothelial synthase genes in the development of acute myocardial infarction (AMI) in patients after a new coronavirus infection.
Material and methods. A case-control study, the study group consisted of patients after COVID-19, confirmed by PCR, of moderate or severe form, for a period of 6 to 24 months, the main group with AMI, the control group without AMI. All patients underwent studies of serum homocysteine and folic acid levels and molecular genetic studies (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, MTRR 66 A>G, NOS3 -786 T>C, NOS3 894 G>T).
Results. In patients after COVID-19, a violation of one-carbon metabolism due to hyperhomocysteinemia was found, as well as a high risk of AMI in middle-aged patients with an increase in homocysteine levels in the blood of more than 14.3 mmol/l and carriage of the NOS3 -786 gene.
Conclusion. An imbalance of one-carbon metabolism markers and the presence of polymorphism of endothelial synthase genes contributes to the development of acute myocardial infarction after COVID-19 in middle-aged patients.
About the authors
D. A. Evteeva
Northwestern State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: doc.evteeva@yandex.ru
ORCID iD: 0000-0001-5756-2088
SPIN-code: 3468-6619
Post-graduate Student, the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015L. B. Gaikovaya
Northwestern State Medical University named after I.I. Mechnikov
Email: larisa.gaikovaya@szgmu.ru
ORCID iD: 0000-0003-1000-1114
SPIN-code: 9424-1076
Dr.Sc. (Med.), Professor, Head of the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015N. V. Vohmyanina
Northwestern State Medical University named after I.I. Mechnikov
Email: spbnat@yandex.ru
ORCID iD: 0000-0002-7162-9362
SPIN-code: 7414-4257
Dr.Sc. (Med.), Professor of the Clinical Laboratory Diagnostics, Biological and General Chemistry Department named after V.V. Sokolovsky
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015T. T. Asatryan
Northwestern State Medical University named after I.I. Mechnikov
Email: Tatevik.Asatryan@szgmu.ru
ORCID iD: 0000-0002-9146-3080
SPIN-code: 5587-1360
Ph.D. (Med.), Associate Professor of the Department of Clinical Laboratory Diagnostics, Biological and General Chemistry named after V.V. Sokolovsky
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015K. A. Shchetinina
Northwestern State Medical University named after I.I. Mechnikov
Email: karishasuper11@gmail.com
ORCID iD: 0009-0002-1675-7166
Student, Fundamental Medicine Institute
Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015References
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