Email this article Hemostasis system and immunomorphologic state of placenta under presence of antiphospholipid antibodies in plasma with consideration of their class and pregnancy outcome
- Authors: Kosheleva N.G.1, Zubzhitskaia L.В.1, Arzhanova О.N.1, Tyshkevich О.V.1, Gromyko Y.1, Shlyakhtenko Т.N.1, Pluzhnikova Т.A.1, Shapovalova Е.А.1
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Affiliations:
- Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Issue: Vol 53, No 1 (2004)
- Pages: 22-26
- Section: Original study articles
- URL: https://medbiosci.ru/jowd/article/view/86971
- DOI: https://doi.org/10.17816/JOWD86971
- ID: 86971
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Abstract
The present study was undertaken to investigate hemostasis system of 197 women with recurrent miscarriage: Analysis placentas by immunomorphology are studied of 41 women and of 52 women with autoimmune antibodies to β2-glycoprotein-I (β2-GPI) in placenta. There was exposed hyperactivation platelets blood of all women with antiphospholipid antibodies irrespective of groups with significantly was increased at the beginning of pregnancy and progressed with growing gestation. As result of investigation it is determined certain connection between outcome of pregnancy and activation degree platelets blood in vasculars. Was found absence influence anticardiolipin antibodies (aCL) on plasmocoagulative link hemostasis. The circulation of lupus anticoagulant (LA) was accompanied indication of hypercoagulation. In all research groups was determined significant oppression of fibrinolisis. Analysis placentas by immunomorphology was determined significantly tissue damages with LA and β2-GPI-dependent aCL.
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##article.viewOnOriginalSite##About the authors
N. G. Kosheleva
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
L. В. Zubzhitskaia
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
О. N. Arzhanova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
О. V. Tyshkevich
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
Y. Gromyko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
Т. N. Shlyakhtenko
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
Т. A. Pluzhnikova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
Е. А. Shapovalova
Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: info@eco-vector.com
Russian Federation, Saint Petersburg
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